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Details for Product No. ABIN654887

Mitogen-Activated Protein Kinase 8 (MAPK8) (AA 159-195), (Thr183), (Tyr185) antibody

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Antigen
Synonyms
JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c, Prkm8, AI849689, BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, ... show more
Epitope
»Alternatives AA 159-195, Thr183, Tyr185
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN654887
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This MAPK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-195 AA from human MAPK8.
Clone RB28968
Isotype Ig
Specificity This JNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-199 amino acids from human JNK1.
Predicted Reactivity Rat (Rattus),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MAPK8
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms: Mitogen-activated protein kinase 8,MAPK8,JNK1, PRKM8, SAPK1
Molecular Weight 48296 DA
Gene ID 5599
UniProt P45983, NP_620637
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Yang, Zheng, Cao et al.: "8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK." in: World journal of gastroenterology : WJG, Vol. 16, Issue 27, pp. 3385-93, 2010 (PubMed).

Dasgupta, Kar, Liu et al.: "Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase." in: Journal of cellular physiology, Vol. 225, Issue 1, pp. 52-62, 2010 (PubMed).

Han, Crowe: "Jun amino-terminal kinase 1 activation promotes cell survival in ErbB2-positive breast cancer." in: Anticancer research, Vol. 30, Issue 9, pp. 3407-12, 2010 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase 8 (MAPK8)", type "Antibodies"
Hosts (98), (64), (2)
Reactivities (150), (42), (34), (4), (2), (2), (2), (2), (1)
Applications (150), (75), (43), (43), (25), (20), (10), (8), (7), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Conjugates (1), (1)
Epitopes (21), (12), (11), (10), (8), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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