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JNK antibody (Mitogen-Activated Protein Kinase 8) (AA 159-195)

Details for Product anti-MAPK8 Antibody No. ABIN654887, Supplier: Log in to see
Antigen
  • BSK
  • BSK/DJNK
  • Bsk
  • CG5680
  • D-JNK
  • D-junk
  • DBSK/JNK
  • DJNK
  • DJNK/bsk
  • Dmel\\CG5680
  • JNK
  • JNK/SAPK
  • Jnk
  • Junk
  • SAPKa
  • c-Jun
  • dJNK
  • jnk
  • JNK-46
  • JNK1
  • JNK1A2
  • JNK21B1/2
  • PRKM8
  • SAPK1
  • SAPK1c
  • AI849689
  • Prkm8
  • jnk1
  • sapk1
  • T10F20.15
  • mapk8
  • zgc:112379
Alternatives
anti-Human JNK antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 159-195, Thr183, Tyr185
95
58
33
21
18
15
15
13
13
13
10
10
10
10
9
5
5
5
5
4
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
363
127
108
17
15
7
6
4
2
2
2
1
1
Host
Rabbit
302
87
2
Clonality (Clone)
Polyclonal ()
Conjugate
This JNK antibody is un-conjugated
18
16
14
11
11
10
4
3
3
3
3
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
288
194
86
61
52
47
39
33
17
12
9
6
3
3
2
2
1
1
1
1
1
1
Supplier
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Immunogen This MAPK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-195 AA from human MAPK8.
Clone RB28968
Isotype Ig
Specificity This JNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-199 amino acids from human JNK1.
Predicted Reactivity Rat (Rattus),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MAPK8 (MAPK8 Antibody Abstract)
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms: Mitogen-activated protein kinase 8,MAPK8,JNK1, PRKM8, SAPK1
Molecular Weight 48296 DA
Gene ID 5599
NCBI Accession NP_620637
UniProt P45983
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Cell Structure
Pathways MAPK Signaling, WNT Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-JNK antibody (Mitogen-Activated Protein Kinase 8) (AA 159-195) (ABIN654887) JNK1-T183/Y185 antibody (ABIN654887) immunohistochemistry analysis in formalin fixed ...
Background publications Han, Crowe: "Jun amino-terminal kinase 1 activation promotes cell survival in ErbB2-positive breast cancer." in: Anticancer research, Vol. 30, Issue 9, pp. 3407-12, 2010 (PubMed).

Dasgupta, Kar, Liu et al.: "Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase." in: Journal of cellular physiology, Vol. 225, Issue 1, pp. 52-62, 2010 (PubMed).

Yang, Zheng, Cao et al.: "8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK." in: World journal of gastroenterology : WJG, Vol. 16, Issue 27, pp. 3385-93, 2010 (PubMed).