Mitogen-Activated Protein Kinase 8 (MAPK8) (AA 159-195), (Thr183), (Tyr185) antibody

Details for Product No. ABIN654887
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Antigen
Synonyms
BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, jnk, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c, AI849689, P ... show more
BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, jnk, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c, AI849689, Prkm8, jnk1, sapk1, T10F20.15, mapk8, zgc:112379 show less
Epitope
AA 159-195, Thr183, Tyr185
(53), (26), (20), (17), (12), (11), (10), (9), (8), (7), (6), (6), (5), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(241), (85), (75), (26), (24), (24), (8), (3), (2), (1), (1), (1)
Host
Rabbit
(191), (68), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(8), (8), (7), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(219), (131), (50), (46), (40), (36), (22), (20), (19), (10), (4), (3), (3), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN654887
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Immunogen This MAPK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-195 AA from human MAPK8.
Clone RB28968
Isotype Ig
Specificity This JNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-199 amino acids from human JNK1.
Predicted Reactivity Rat (Rattus),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MAPK8
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms: Mitogen-activated protein kinase 8,MAPK8,JNK1, PRKM8, SAPK1
Molecular Weight 48296 DA
Gene ID 5599
NCBI Accession NP_620637
UniProt P45983
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase 8 (MAPK8) (AA 159-195), (Thr183), (Tyr185) antibody JNK1-T183/Y185 antibody (ABIN654887) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
Background publications Yang, Zheng, Cao et al.: "8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK." in: World journal of gastroenterology : WJG, Vol. 16, Issue 27, pp. 3385-93, 2010 (PubMed).

Dasgupta, Kar, Liu et al.: "Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase." in: Journal of cellular physiology, Vol. 225, Issue 1, pp. 52-62, 2010 (PubMed).

Han, Crowe: "Jun amino-terminal kinase 1 activation promotes cell survival in ErbB2-positive breast cancer." in: Anticancer research, Vol. 30, Issue 9, pp. 3407-12, 2010 (PubMed).

Validation Images
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