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Details for Product No. ABIN655049

Lysyl-tRNA Synthetase (KARS) (N-Term), (AA 70-98) antibody

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Antigen
Synonyms
CMTRIB, DFNB89, KARS1, KARS2, KRS, LysRS, AA589550, AL024334, AL033315, AL033367, D8Wsu108e, mKIAA0070, D8Ertd698e, CG12141, Dmel\\CG12141, cb530, wu:fa16h02, zgc:92483, kars, MGC53345, kars2, krs, kr ... show more
Epitope
»Alternatives N-Term, AA 70-98
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN655049
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This KARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 AA from the N-terminal region of human KARS.
Clone RB14918
Isotype Ig
Specificity This KARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the N-terminal region of human KARS.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name KARS
Background Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: Lysyl-tRNA synthetase,KARS,KIAA0070
Molecular Weight 68048 DA
Gene ID 3735
UniProt Q15046, NP_005539.1, NP_001123561.1
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin
Application Notes Recommend dilutions: WB : 1:1000,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Kawamata, Magrané, Kunst et al.: "Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28321-8, 2008 (PubMed).

McLaughlin, Sakaguchi, Liu et al.: "Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy." in: American journal of human genetics, Vol. 87, Issue 4, pp. 560-6, 2010 (PubMed).

Alternatives for antigen "Lysyl-tRNA Synthetase (KARS)", type "Antibodies"
Hosts (29), (8)
Reactivities (34), (19), (15), (13), (12), (12), (12)
Applications (28), (15), (10), (9), (8), (3), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (2), (1), (1)
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