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KARS Products

(Lysyl-tRNA Synthetase (KARS))
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured KARS Categories

KARS Antibodies

High quality antibodies with extensive validation data.

KARS ELISA Kits

Reliable ELISA kits for a wide range of species.

KARS Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KARS Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN7268350
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (4)
  • (3)
Cat. No. ABIN969226
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), IF, ICC
Validations
  • (4)
Cat. No. ABIN2855293
Quantity 100 μL
Datasheet Datasheet

Recommended KARS ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957609
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957610
Quantity 96 tests
Datasheet Datasheet

Recommended KARS Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308352
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123818
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095758
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our KARS products

Guo, Ignatov, Musier-Forsyth, Schimmel, Yang: "Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 7, pp. 2331-6, (2008) (PubMed).

Kaminska, Francin, Shalak, Mirande: "Role of HIV-1 Vpr-induced apoptosis on the release of mitochondrial lysyl-tRNA synthetase." in: FEBS letters, Vol. 581, Issue 16, pp. 3105-10, (2007) (PubMed).

Kovaleski, Kennedy, Khorchid, Kleiman, Matsuo, Musier-Forsyth: "Critical role of helix 4 of HIV-1 capsid C-terminal domain in interactions with human lysyl-tRNA synthetase." in: The Journal of biological chemistry, Vol. 282, Issue 44, pp. 32274-9, (2007) (PubMed).

Sampath, Mazumder, Seshadri, Gerber, Chavatte, Kinter, Ting, Dignam, Kim, Driscoll, Fox: "Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation." in: Cell, Vol. 119, Issue 2, pp. 195-208, (2004) (PubMed).

Sang Lee, Gyu Park, Park, Seol, Lee, Kim: "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex." in: Biochemical and biophysical research communications, Vol. 291, Issue 1, pp. 158-64, (2002) (PubMed).

Cen, Khorchid, Javanbakht, Gabor, Stello, Shiba, Musier-Forsyth, Kleiman: "Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1." in: Journal of virology, Vol. 75, Issue 11, pp. 5043-8, (2001) (PubMed).

Tolkunova, Park, Xia, King, Davidson: "The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript." in: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35063-9, (2000) (PubMed).

Synonyms and alternative names related to KARS

Lysyl-tRNA synthetase (LysRS), lysyl-tRNA synthetase (kars), lysyl-tRNA synthetase S homeolog (kars.S), lysyl-tRNA synthetase L homeolog (kars.L), lysyl-tRNA synthetase (Bm1_16500), lysyl-tRNA synthetase (lysS), Lysyl-tRNA synthetase (lysS), lysyl-tRNA synthetase (Taci_1118), lysyl-tRNA synthetase (Tpau_1737), lysyl-tRNA synthetase (Arch_0261), lysyl-tRNA synthetase (Trad_2960), lysyl-tRNA synthetase (Spirs_3699), lysyl-tRNA synthetase (KARS), lysyl-tRNA synthetase (LOC100280510), lysyl-tRNA synthetase (Tb927.6.1510), lysyl-tRNA synthetase (Kars), AA589550, AL024334, AL033315, AL033367, cb530, CG12141, CMTRIB, D8Ertd698e, D8Wsu108e, DFNB89, Dmel\\CG12141, kars, KARS, KARS1, kars2, KARS2, KRS, krs, krs-1, LysRS, MGC53345, mKIAA0070, Tb06.28P18.190, wu:fa16h02, zgc:92483

Protein level used designations for KARS

  • Aats-lys-PA
  • Aats-lys-PB
  • Aats-lys-PC
  • CG12141-PA
  • CG12141-PB
  • CG12141-PC
  • fa16h02
  • lysine--tRNA ligase
  • lysyl-tRNA synthetase
  • lysRS
  • lysine tRNA ligase
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