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Nibrin antibody (NBN) (AA 602-630)

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Antigen
Synonyms NBN, AT-V1, AT-V2, ATV, NBS, NBS1, P95, Nbs1, im:6911679, zgc:194152
Alternatives
Epitope
AA 602-630, C-Term
(45), (32), (16), (13), (13), (12), (10), (6), (6), (5), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(262), (60), (50), (4), (1)
Host
Rabbit
(190), (78)
Clonality (Clone)
Polyclonal ()
Conjugate
This Nibrin antibody is un-conjugated
(6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
(223), (71), (58), (51), (41), (29), (24), (21), (18), (5), (3), (2), (1)
Pubmed 3 references available
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Quantity 400 μL
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Immunogen This NBN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 602-630 AA from the C-terminal region of human NBN.
Clone RB19072
Isotype Ig
Specificity This NBN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 609-638 amino acids from the C-terminal region of human NBN.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NBN (NBN Antibody Abstract)
Background Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Synonyms: NBN,Nibrin,NBS, NBS1, P95
Molecular Weight 84959 DA
Gene ID 4683
NCBI Accession NP_002476
UniProt O60934
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Chromatin, Signaling, Cell Structure
Pathways DNA Damage Repair
Application Notes WB = 1:1000, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.27 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Nibrin antibody (NBN) (AA 602-630) (ABIN655721) NBN Antibody (C-term) western blot analysis in NCI-H460,NCI-H292 cell line lysates (...
Immunofluorescence (IF) image for anti-Nibrin antibody (NBN) (AA 602-630) (ABIN655721) Confocal immunofluorescent analysis of NBN Antibody (C-term) with Hela cell followed...
Flow Cytometry (FACS) image for anti-Nibrin antibody (NBN) (AA 602-630) (ABIN655721) NBN Antibody (C-term) flow cytometric analysis of NCI-H460 cells (right histogram) c...
Background publications Kavitha, Choudhary, Raghavan et al.: "Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells." in: Biochemical and biophysical research communications, Vol. 399, Issue 4, pp. 575-80, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Liu, Shete, Wang et al.: "Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk." in: Carcinogenesis, Vol. 31, Issue 10, pp. 1762-9, 2010 (PubMed).

Catalog No. ABIN655721
$324.50
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