Nibrin antibody (NBN) (AA 467-615)

Details for Product anti-NBN Antibody No. ABIN1724942, Supplier: Log in to see
Antigen
  • NBN
  • AT-V1
  • AT-V2
  • ATV
  • NBS
  • NBS1
  • P95
  • Nbs1
  • im:6911679
  • zgc:194152
  • nibrin
  • NBN
  • nbn
  • Nbn
Alternatives
anti-Human Nibrin antibody for Immunoprecipitation
Epitope
AA 467-615
48
32
24
16
15
10
9
8
6
6
6
4
4
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
280
89
66
5
1
1
1
1
Host
Mouse
209
77
Clonality (Clone)
Monoclonal ()
Conjugate
This Nibrin antibody is un-conjugated
6
5
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
245
100
87
50
49
27
26
19
15
8
5
3
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of human NBN (AA 467-615) expressed in E. Coli.
Clone 7E4C2
Isotype IgG2a
Purification Purified
Plasmids, Primers & others Plasmids, Primers & others Nibrin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name NBN (NBN Antibody Abstract)
Background Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. ,
Molecular Weight 85 kDa
Gene ID 4683
HGNC 4683
Pathways DNA Damage Repair, Production of Molecular Mediator of Immune Response
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
ELISA image for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) anti-Nibrin (NBN) (AA 467-615) antibody
Flow Cytometry (FACS) image for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) anti-Nibrin (NBN) (AA 467-615) antibody (Image 2)
Immunocytochemistry (ICC) image for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) anti-Nibrin (NBN) (AA 467-615) antibody (Image 3)
Western Blotting (WB) image for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) anti-Nibrin (NBN) (AA 467-615) antibody (Image 4)
Western Blotting (WB) image for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) anti-Nibrin (NBN) (AA 467-615) antibody (Image 5)
Western Blotting (WB) image for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) anti-Nibrin (NBN) (AA 467-615) antibody (Image 6)
Immunohistochemistry (IHC) image for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using NBN m...
Immunohistochemistry (IHC) image for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) Immunohistochemical analysis of paraffin-embedded colon cancer tissues using NBN mous...
Product cited in: Zuhlke, Johnson, Okoth, Stoffel, Robbins, Tembe, Salinas, Zheng, Xu, Carpten, Lange, Isaacs, Cooney: "Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer." in: Familial cancer, Vol. 11, Issue 4, pp. 595-600, 2012 (PubMed).

Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: "Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma." in: Molecular carcinogenesis, Vol. 50, Issue 9, pp. 689-96, 2011 (PubMed).

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