Nibrin antibody (NBN) (AA 467-615)

Details for Product anti-NBN Antibody No. ABIN1724942
Antigen
Epitope
AA 467-615
59
32
22
16
15
9
9
8
7
6
6
6
4
4
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
308
114
90
5
1
1
1
1
Host
Mouse
241
73
Clonality (Clone)
Monoclonal ()
Conjugate
This Nibrin antibody is un-conjugated
12
8
8
8
8
8
8
5
3
2
2
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
246
97
90
55
46
29
26
18
14
7
6
4
3
2
1
1
Options
Immunogen Purified recombinant fragment of human NBN (AA 467-615) expressed in E. Coli.
Clone 7E4C2
Isotype IgG2a
Purification Purified
Antigen
Alternative Name NBN (NBN Antibody Abstract)
Background Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. ,
Molecular Weight 85 kDa
Gene ID 4683
HGNC 4683
Pathways DNA Damage Repair, Production of Molecular Mediator of Immune Response
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) Immunohistochemical analysis of paraffin-embedded colon cancer tissues using NBN mous...
Image no. 2 for anti-Nibrin (NBN) (AA 467-615) antibody (ABIN1724942) Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using NBN m...
Product cited in: Zuhlke, Johnson, Okoth, Stoffel, Robbins, Tembe, Salinas, Zheng, Xu, Carpten, Lange, Isaacs, Cooney: "Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer." in: Familial cancer, Vol. 11, Issue 4, pp. 595-600, 2012 (PubMed).

Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: "Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma." in: Molecular carcinogenesis, Vol. 50, Issue 9, pp. 689-96, 2011 (PubMed).