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HCLS1 Associated Protein X-1 (HAX1) (AA 161-190), (C-Term) antibody

Details for Product No. ABIN656245, Supplier: Login to see
Antigen
  • HAX1
  • hax1
  • HCLSBP1
  • HS1BP1
  • SCN3
  • HAX-1
  • Hs1bp1
  • HSP1BP-1
  • SIG-111
  • Silg111
  • mHAX-1s
Epitope
AA 161-190, C-Term
16
14
13
10
10
4
3
3
2
1
1
1
1
1
1
Reactivity
Human
121
29
29
1
1
1
Host
Rabbit
77
29
15
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
8
8
8
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
98
70
35
11
7
6
4
2
1
1
Supplier
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Immunogen This HAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 AA from the C-terminal region of human HAX1.
Clone RB31099
Isotype Ig
Specificity This HAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-190 amino acids from the C-terminal region of human HAX1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HAX1 (HAX1 Antibody Abstract)
Background The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms: HAX1,HCLS1-associated protein X-1,HS1BP1
Molecular Weight 31621 DA
Gene ID 10456
NCBI Accession NP_006109, NP_001018238
UniProt O00165
Research Area Signaling, Cell Structure, Protein Modifications
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment HAX1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-HCLS1 Associated Protein X-1 (HAX1) (AA 161-190), (C-Term) antibody (ABIN656245) HAX1 Antibody (C-term) (ABIN656245) immunohistochemistry analysis in formalin fixed a...
Background publications Han, Goldstein, Hou et al.: "Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22461-72, 2010 (PubMed).