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Details for Product No. ABIN656245

HCLS1 Associated Protein X-1 (HAX1) (C-Term), (AA 161-190) antibody

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Synonyms HCLSBP1, HS1BP1, SCN3, HAX-1, Hs1bp1, HSP1BP-1, SIG-111, Silg111, mHAX-1s, HAX1, hax1
»Alternatives C-Term, AA 161-190
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN656245
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This HAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 AA from the C-terminal region of human HAX1.
Clone RB31099
Isotype Ig
Specificity This HAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-190 amino acids from the C-terminal region of human HAX1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HAX1
Background The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms: HAX1,HCLS1-associated protein X-1,HS1BP1
Molecular Weight 31621 DA
Gene ID 10456
UniProt NP_001018238.1, NP_006109.2, O00165
Research Area Signaling, Cell Structure, Protein Modifications
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment HAX1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Han, Goldstein, Hou et al.: "Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22461-72, 2010 (PubMed).

Alternatives for antigen "HCLS1 Associated Protein X-1 (HAX1)", type "Antibodies"
Hosts (36), (29), (6)
Reactivities (72), (19), (17), (12), (12), (11)
Applications (58), (49), (9), (8), (4)
Conjugates (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (22), (8), (5), (3), (2), (2), (1), (1), (1)