Paired Box 6 (PAX6) antibody

Details for Product No. ABIN656844
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Antigen
Synonyms
pax6, an2, mgda, wagr, pax-6, pax6a, xpax6, XLPAX6, MGC52531, PAX-6, AN, AN2, D11S812E, MGDA, WAGR, Pax-6, pax6b, 1500038E17Rik, AEY11, Dey, Gsfaey11, Sey, PAXZF-A, Pax6.1, cb280, fc20e07, pax-a, pax[ ... show more
pax6, an2, mgda, wagr, pax-6, pax6a, xpax6, XLPAX6, MGC52531, PAX-6, AN, AN2, D11S812E, MGDA, WAGR, Pax-6, pax6b, 1500038E17Rik, AEY11, Dey, Gsfaey11, Sey, PAXZF-A, Pax6.1, cb280, fc20e07, pax-a, pax[zf-a], paxzfa, wu:fc20e07, zfpax-6a, zfpax-6b show less
Reactivity
Human
(99), (36), (33), (15), (14), (14), (6), (6), (2), (1)
Host
Rabbit
(76), (26), (6)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(93), (51), (22), (20), (17), (10), (9), (8), (4), (4), (3), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN656844
291.50 $
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Immunogen This PAX6 antibody is generated from rabbits immunized with a recombinant protein from human PAX6.
Clone RB22657
Isotype Ig
Specificity This PAX6 antibody is generated from rabbits immunized with a recombinant protein from human PAX6.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PAX6
Background This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq].
Synonyms: Paired box protein Pax-6,PAX6,AN2
Molecular Weight 46683 DA
Gene ID 5080
NCBI Accession NP_001121084, NP_001595, NP_000271
UniProt P26367
Research Area Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment PAX6 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Paired Box 6 (PAX6) antibody PAX6 Antibody (ABIN656844) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Vuzman, Polonsky, Levy: "Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker." in: Biophysical journal, Vol. 99, Issue 4, pp. 1202-11, 2010 (PubMed).

Gosmain, Marthinet, Cheyssac et al.: "Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33381-93, 2010 (PubMed).

Validation Images
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