Paired Box 6 (PAX6) antibody

Antigen: Paired Box 6 (PAX6)

Synonyms: AN, AN2, MGDA, WAGR, D11S812E, MGC17209, Dey, Sey, AEY11, Pax-6, Gsfaey11, 1500038E17Rik, pax-6, an2, mgda, wagr, pax6a, xpax6, XLPAX6, MGC52531, PAX6, pax6, pax6b, PAX-6

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN656844

Additional Information

Alternative name: PAX6

Gene ID: 5080

UniProt: NP_001595.2, NP_001121084.1, P26367, NP_000271.1

Immunogen: This PAX6 antibody is generated from rabbits immunized with a recombinant protein from human PAX6.

Isotype: Ig

Description: Other names: Paired box protein Pax-6,PAX6,AN2

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This PAX6 antibody is generated from rabbits immunized with a recombinant protein from human PAX6.

Molecular Weight: 46683 DA

Comments:

Background: This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq].

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: PAX6 Antibody can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

PAX6 Antibody (ABIN656844) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PAX6 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Gosmain, Marthinet, Cheyssac et al.: "Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33381-93, 2010 (PubMed).

Vuzman, Polonsky, Levy: "Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker." in: Biophysical journal, Vol. 99, Issue 4, pp. 1202-11, 2010 (PubMed).