Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2) (C-Term), (AA 572-601) antibody

Details for Product No. ABIN656926
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Antigen
Synonyms lapser1, MGC89253, si:dkey-250a11.1, LAPSER1, BC014695, mKIAA1813, Lapser1
Epitope
C-Term, AA 572-601
(16), (10), (8), (1), (1)
Reactivity
Human
(28), (8), (1), (1), (1)
Host
Rabbit
(27), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(20), (19), (5), (5), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN656926
291.50 $
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Immunogen This LZTS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-601 AA from the C-terminal region of human LZTS2.
Clone RB32641
Isotype Ig
Specificity This LZTS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-601 amino acids from the C-terminal region of human LZTS2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name LZTS2
Background Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
Synonyms: Leucine zipper putative tumor suppressor 2,LZTS2,KIAA1813, LAPSER1
Molecular Weight 72759 DA
Gene ID 84445
NCBI Accession NP_115805
UniProt Q9BRK4
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment LZTS2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2) (C-Term), (AA 572-601) antibody LZTS2 Antibody (C-term) (ABIN656926) western blot analysis in WiDr cell line lysates (35 µg/lane). This demonstrates the LZTS2 antibody detected the LZTS2 protein (arrow).
Background publications Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Hyun Hwa Cho, Hye Joon Joo, Ji Sun Song et al.: "Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells." in: Biochimica et biophysica acta, Vol. 1783, Issue 3, pp. 419-28, 2008 (PubMed).

Validation Images
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