LZTS2 antibody (C-Term)

Catalog No. ABIN6991079

The Rabbit Polyclonal anti-LZTS2 antibody is suitable to detect LZTS2 in samples from Human. It has been validated for ELISA and IHC (p).

Quick Overview for LZTS2 antibody (C-Term) (ABIN6991079)

Target: LZTS2 (Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LZTS2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LZTS2 Antibody

Binding Specificity: AA 570-620, C-Term

Specificity: LZTS2 antibody is predicted to not cross-react with other LZTS family members.

Purification: LZTS2 Antibody is affinity chromatography purified via peptide column.

Immunogen: LZTS2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human LZTS2. The immunogen is located within amino acids 570 - 620 of LZTS2.

Isotype: IgG

Application Details

Application Notes: LZTS2 antibody can be used for detection of LZTS2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LZTS2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LZTS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for LZTS2

Target: LZTS2 (Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2))

Alternative Name: LZTS2

Background: LZTS2 Antibody: The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.

Gene ID: 84445

NCBI Accession: NP_115805

UniProt: Q9BRK4