You are viewing an incomplete version of our website. Please click to reload the website as full version.

B-Cell CLL/lymphoma 6 (BCL6) (AA 676-704), (C-Term) antibody

Details for Product No. ABIN656985, Supplier: Log in to see
Antigen
  • bcl5
  • laz3
  • bcl6a
  • znf51
  • zbtb27
  • MGC132260
  • Bcl5
  • BCL5
  • BCL6A
  • LAZ3
  • ZBTB27
  • ZNF51
Epitope
AA 676-704, C-Term
50
13
10
8
7
6
6
6
6
5
4
4
4
3
2
2
2
2
1
1
1
Reactivity
Human
152
77
45
9
3
3
1
1
1
1
Host
Rabbit
96
52
7
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
9
8
7
4
4
3
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
102
60
32
28
21
18
16
11
6
2
1
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen This BCL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 676-704 AA from the C-terminal region of human BCL6.
Clone RB32973
Isotype Ig
Specificity This BCL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 675-704 amino acids from the C-terminal region of human BCL6.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BCL6 (BCL6 Antibody Abstract)
Background The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Synonyms: B-cell lymphoma 6 protein,BCL6,BCL5, LAZ3, ZBTB27, ZNF51
Molecular Weight 78846 DA
Gene ID 604
NCBI Accession NP_001128210, NP_001697, NP_001124317
UniProt P41182
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Signaling, Chromatin, Cell Structure
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment BCL6 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 676-704), (C-Term) antibody (ABIN656985) BCL6 Antibody (C-term) (ABIN656985) western blot analysis in Hela cell line lysates (...
Background publications Chang, Vlad, DAgati et al.: "BCL6 is required for differentiation of Ig-like transcript 3-Fc-induced CD8+ T suppressor cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 5714-22, 2010 (PubMed).

Lai, Fatemi, Dhasarathy et al.: "DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas." in: The Journal of experimental medicine, Vol. 207, Issue 9, pp. 1939-50, 2010 (PubMed).

Yang, Huang, Chatterjee et al.: "A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 29760-9, 2010 (PubMed).

Ramachandrareddy, Bouska, Shen et al.: "BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 26, pp. 11930-5, 2010 (PubMed).