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Details for Product No. ABIN656985

B-Cell CLL/lymphoma 6 (BCL6) (C-Term), (AA 676-704) antibody

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Antigen
Synonyms BCL5, LAZ3, BCL6A, ZNF51, ZBTB27, Bcl5, bcl5, laz3, bcl6a, znf51, zbtb27, MGC132260
Epitope
»Alternatives C-Term, AA 676-704
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN656985
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This BCL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 676-704 AA from the C-terminal region of human BCL6.
Clone RB32973
Isotype Ig
Specificity This BCL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 675-704 amino acids from the C-terminal region of human BCL6.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BCL6
Background The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Synonyms: B-cell lymphoma 6 protein,BCL6,BCL5, LAZ3, ZBTB27, ZNF51
Molecular Weight 78846 DA
Gene ID 604
UniProt P41182, NP_001128210.1, NP_001124317.1, NP_001697.2
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment BCL6 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Ramachandrareddy, Bouska, Shen et al.: "BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 26, pp. 11930-5, 2010 (PubMed).

Yang, Huang, Chatterjee et al.: "A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 29760-9, 2010 (PubMed).

Lai, Fatemi, Dhasarathy et al.: "DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas." in: The Journal of experimental medicine, Vol. 207, Issue 9, pp. 1939-50, 2010 (PubMed).

Chang, Vlad, DAgati et al.: "BCL6 is required for differentiation of Ig-like transcript 3-Fc-induced CD8+ T suppressor cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 5714-22, 2010 (PubMed).

Alternatives for antigen "B-Cell CLL/lymphoma 6 (BCL6)", type "Antibodies"
Hosts (42), (15)
Reactivities (54), (22), (18), (1), (1), (1), (1)
Applications (38), (20), (15), (7), (6), (6), (6), (3), (2), (1), (1), (1)
Epitopes (12), (5), (5), (4), (3), (3), (2), (1), (1), (1)
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