alpha Ketoglutarate Dehydrogenase (alphaKGDHC) (C-Term), (AA 381-410) antibody

Details for Product No. ABIN657365
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Antigen
Epitope
C-Term, AA 381-410
(7), (6), (3), (1)
Reactivity
Human
(19), (4), (4), (1), (1), (1)
Host
Rabbit
(19)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(19), (14), (10), (3), (2), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN657365
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Immunogen This OGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-410 AA from the C-terminal region of human OGDH.
Clone RB32469
Isotype Ig
Specificity This OGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-410 amino acids from the C-terminal region of human OGDH.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name OGDH
Background This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: 2-oxoglutarate dehydrogenase, mitochondrial,OGDH,
Molecular Weight 115935 DA
Gene ID 4967
NCBI Accession NP_002532
UniProt Q02218
Research Area Ubiquitin-related antibodies, Signaling, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment OGDH Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-alpha Ketoglutarate Dehydrogenase (alphaKGDHC) (C-Term), (AA 381-410) antibody OGDH Antibody (C-term) (ABIN657365) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the OGDH antibody detected the OGDH protein (arrow).
Background publications McCartney, Rice, Sanderson et al.: "Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24158-64, 1998 (PubMed).

Habelhah, Laine, Erdjument-Bromage et al.: "Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah." in: The Journal of biological chemistry, Vol. 279, Issue 51, pp. 53782-8, 2004 (PubMed).

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