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Details for Product No. ABIN657365

alpha Ketoglutarate Dehydrogenase (alphaKGDHC) (C-Term), (AA 381-410) antibody

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Antigen
Synonyms 2210403E04Rik, 2210412K19Rik, AA409584, d1401, mKIAA4192, AKGDH, E1k, OGDC
Epitope
»Alternatives C-Term, AA 381-410
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN657365
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This OGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-410 AA from the C-terminal region of human OGDH.
Clone RB32469
Isotype Ig
Specificity This OGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-410 amino acids from the C-terminal region of human OGDH.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name OGDH
Background This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: 2-oxoglutarate dehydrogenase, mitochondrial,OGDH,
Molecular Weight 115935 DA
Gene ID 4967
UniProt NP_002532.2, Q02218
Research Area Ubiquitin-related antibodies, Signaling, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment OGDH Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications McCartney, Rice, Sanderson et al.: "Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24158-64, 1998 (PubMed).

Habelhah, Laine, Erdjument-Bromage et al.: "Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah." in: The Journal of biological chemistry, Vol. 279, Issue 51, pp. 53782-8, 2004 (PubMed).

Alternatives for antigen "alpha Ketoglutarate Dehydrogenase (alphaKGDHC)", type "Antibodies"
Hosts (10)
Reactivities (9), (4), (4), (1), (1), (1)
Applications (10), (5), (4), (2), (1)
Epitopes (2), (2), (1), (1)
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