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Details for Product No. ABIN657623

Histone Cluster 2, H2aa3 (HIST2H2AA3) (N-Term), (AA 2-30) antibody

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Antigen
Synonyms H2A, H2A.2, H2A/O, H2A/q, H2AFO, H2a-615, HIST2H2AA, Hist2h2aa3, Hist2h2aa, Hist2h2aa1
Epitope
»Alternatives N-Term, AA 2-30
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN657623
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This HIST2H2AA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 AA from the N-terminal region of human HIST2H2AA3.
Clone RB33628
Isotype Ig
Specificity This HIST2H2AA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST2H2AA3.
Predicted Reactivity Cow (Bovine),Chicken,Caenorhabditis elegans (C. elegans),Mouse (Murine),Monkey,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HIST2H2AA3
Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated, this record represents the centromeric copy.
Synonyms: Histone H2A type 2-A,HIST2H2AA3,H2AFO, HIST2H2AA
Molecular Weight 14095 DA
Gene ID 8337, 723790, 723790
NCBI Accession NP_001035807.1, NP_003507.1
UniProt Q6FI13
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment HIST2H2AA3 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Hagiwara, Hidaka, Yamada: "Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes." in: Biochemistry, Vol. 44, Issue 15, pp. 5827-34, 2005 (PubMed).

Bonenfant, Coulot, Towbin et al.: "Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 3, pp. 541-52, 2006 (PubMed).

Cao, Tsukada, Zhang: "Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing." in: Molecular cell, Vol. 20, Issue 6, pp. 845-54, 2005 (PubMed).

Boyne, Pesavento, Mizzen et al.: "Precise characterization of human histones in the H2A gene family by top down mass spectrometry." in: Journal of proteome research, Vol. 5, Issue 2, pp. 248-53, 2006 (PubMed).

Bergink, Salomons, Hoogstraten et al.: "DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A." in: Genes & development, Vol. 20, Issue 10, pp. 1343-52, 2006 (PubMed).

Alternatives for antigen "Histone Cluster 2, H2aa3 (HIST2H2AA3)", type "Antibodies"
Hosts (5), (1)
Reactivities (5), (1), (1), (1), (1)
Applications (6), (1), (1)
Epitopes (2), (1), (1), (1), (1), (1), (1)
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