CD27 Molecule (CD27) (C-Term), (AA 196-225) antibody

Details for Product No. ABIN657662
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Antigen
Epitope
C-Term, AA 196-225
(14), (12), (9), (7), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(184), (94), (38), (17), (17), (17), (7)
Host
Rabbit
(100), (68), (52), (5), (4), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(32), (27), (17), (11), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(174), (44), (37), (25), (23), (14), (11), (10), (9), (5), (4), (2), (2), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN657662
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Immunogen This CD27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-225 AA from the C-terminal region of human CD27.
Clone RB33726
Isotype Ig
Specificity This CD27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-225 amino acids from the C-terminal region of human CD27.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CD27
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Synonyms: CD27 antigen,CD27,TNFRSF7
Molecular Weight 29137 DA
Gene ID 939
NCBI Accession NP_001233
UniProt P26842
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.49 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment CD27 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-CD27 Molecule (CD27) (C-Term), (AA 196-225) antibody Western blot analysis of CD27 (arrow) using rabbit polyclonal CD27 Antibody (C-term) (ABIN657662). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CD27 gene.
Background publications Arimoto-Miyamoto, Kadowaki, Kitawaki et al.: "Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation." in: Immunology, Vol. 130, Issue 1, pp. 137-49, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Mizuochi, Ito, Saito et al.: "Possible recruitment of peripheral blood CXCR3+ CD27+ CD19+ B cells to the liver of chronic hepatitis C patients." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 30, Issue 4, pp. 243-52, 2010 (PubMed).

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