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VAV1 antibody (Vav 1 Oncogene) (AA 437-466)

Details for Product anti-VAV1 Antibody No. ABIN657774, Supplier: Login to see New
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Antigen
Synonyms VAV, Vav, vav-T
Alternatives
Epitope
AA 437-466, Center
(37), (21), (19), (15), (13), (10), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(147), (66), (63), (2), (1), (1), (1)
Host
Rabbit
(134), (13)
Clonality (Clone)
Polyclonal ()
Conjugate
This VAV1 antibody is un-conjugated
(3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(123), (56), (23), (14), (11), (8), (6), (4), (2), (1), (1), (1)
Pubmed 2 references available
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Quantity 400 μL
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Immunogen This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 AA from the Central region of human VAV1.
Clone RB33825
Isotype Ig
Specificity This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 436-466 amino acids from the Central region of human VAV1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name VAV1 (VAV1 Antibody Abstract)
Background The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Synonyms: Proto-oncogene vav,VAV1,VAV
Molecular Weight 98314 DA
Gene ID 7409
NCBI Accession NP_005419
UniProt P15498
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Structure
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment VAV1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-VAV1 antibody (Vav 1 Oncogene) (AA 437-466) (ABIN657774) VAV1 Antibody (Center) (ABIN657774) western blot analysis in CEM cell line lysates (3...
Background publications Barda-Saad, Shirasu, Pauker et al.: "Cooperative interactions at the SLP-76 complex are critical for actin polymerization." in: The EMBO journal, Vol. 29, Issue 14, pp. 2315-28, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Catalog No. ABIN657774
$324.50
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