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VAV1 antibody (Vav 1 Oncogene) (AA 437-466)

Details for Product anti-VAV1 Antibody No. ABIN657774, Supplier: Login to see
Antigen
  • VAV
  • Vav
  • vav-T
Alternatives
anti-Human VAV1 antibody for Western Blotting
Epitope
AA 437-466, Center
37
21
19
15
13
10
5
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
144
65
63
2
1
1
1
Host
Rabbit
131
13
Clonality (Clone)
Polyclonal ()
Conjugate
This VAV1 antibody is un-conjugated
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
120
56
23
14
11
8
6
4
2
1
1
1
Supplier
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Immunogen This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 AA from the Central region of human VAV1.
Clone RB33825
Isotype Ig
Specificity This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 436-466 amino acids from the Central region of human VAV1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name VAV1 (VAV1 Antibody Abstract)
Background The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Synonyms: Proto-oncogene vav,VAV1,VAV
Molecular Weight 98314 DA
Gene ID 7409
NCBI Accession NP_005419
UniProt P15498
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Structure
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment VAV1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-VAV1 antibody (Vav 1 Oncogene) (AA 437-466) (ABIN657774) VAV1 Antibody (Center) (ABIN657774) western blot analysis in CEM cell line lysates (3...
Background publications Barda-Saad, Shirasu, Pauker et al.: "Cooperative interactions at the SLP-76 complex are critical for actin polymerization." in: The EMBO journal, Vol. 29, Issue 14, pp. 2315-28, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).