VAV1 antibody (pTyr174)

Catalog No. ABIN6256653

Product Details anti-VAV1 Antibody

Target: VAV1 (Vav 1 Oncogene (VAV1))

Binding Specificity: pTyr174

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VAV1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Phospho-VAV1 (Tyr174) Antibody detects endogenous levels of VAV1 only when phosphorylated at Tyrosine 174.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human VAV1 around the phosphorylation site of Tyr174.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

References for anti-VAV1 antibody (ABIN6256653)

Kuai, Luo, Qu, Ru, Luo, Ding, Xing, Liu, Sun, Li, Li: "Transcriptomic Analysis of the Mechanisms for Alleviating Psoriatic Dermatitis Using Taodan Granules in an Imiquimod-Induced Psoriasis-like Mouse Model." in: Frontiers in pharmacology, Vol. 12, pp. 632414, (2021) (PubMed).

Target Details for VAV1

Target: VAV1 (Vav 1 Oncogene (VAV1))

Alternative Name: VAV1 (VAV1 Products)

Synonyms: VAV antibody, Vav antibody, vav-T antibody, vav guanine nucleotide exchange factor 1 antibody, vav 1 oncogene antibody, vav guanine nucleotide exchange factor 1 L homeolog antibody, VAV1 antibody, Vav1 antibody, vav1.L antibody

Background:

Description: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Gene: VAV1

Molecular Weight: 95kDa

Gene ID: 7409

UniProt: P15498

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling