VAV1 antibody (AA 100-200)

Catalog No. ABIN7271302

Product Details anti-VAV1 Antibody

Target: VAV1 (Vav 1 Oncogene (VAV1))

Binding Specificity: AA 100-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VAV1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: VAV1 Rabbit pAb

Sequence: FDVQDFGKVI YTLSALSWTP IAQNRGIMPF PTEEESVGDE DIYSGLSDQI DDTVEEDEDL YDCVENEEAE GDEIYEDLMR SEPVSMPPKM TEYDKRCCCL R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human VAV1 (NP_005419.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for VAV1

Target: VAV1 (Vav 1 Oncogene (VAV1))

Alternative Name: VAV1 (VAV1 Products)

Synonyms: VAV antibody, Vav antibody, vav-T antibody, vav guanine nucleotide exchange factor 1 antibody, vav 1 oncogene antibody, vav guanine nucleotide exchange factor 1 L homeolog antibody, VAV1 antibody, Vav1 antibody, vav1.L antibody

Background: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,VAV1,VAV,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,G protein signaling,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Cell differentiation,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,VAV1

Molecular Weight: 94kDa/98kDa

Gene ID: 7409

UniProt: P15498

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling