Telomeric Repeat Binding Factor 2 (TERF2) (AA 308-337), (Center) antibody

Details for Product No. ABIN657781
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Antigen
Synonyms TRF2, TRBF2, trf2, TERF2
Epitope
AA 308-337, Center
(6), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(38), (9), (5), (2), (2), (1)
Host
Rabbit
(21), (11), (9)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(36), (13), (12), (10), (9), (7), (4), (3), (2), (2), (2), (2), (2), (1)
Pubmed 3 references available
Catalog no. ABIN657781
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This TERF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 AA from the Central region of human TERF2.
Clone RB33900
Isotype Ig
Specificity This TERF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-337 amino acids from the Central region of human TERF2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TERF2
Background This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Synonyms: Telomeric repeat-binding factor 2,TERF2,TRBF2, TRF2
Molecular Weight 55551 DA
Gene ID 7014
UniProt Q15554, NP_005643.1
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment TERF2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Telomeric Repeat Binding Factor 2 (TERF2) (AA 308-337), (Center) antibody TERF2 Antibody (Center) (ABIN657781) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane). This demonstrates the TERF2 antibody detected the TERF2 protein (arrow).
Background publications Bombarde, Boby, Gomez et al.: "TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends." in: The EMBO journal, Vol. 29, Issue 9, pp. 1573-84, 2010 (PubMed).

Prescott, McGrath, Lee et al.: "Telomere length and genetic analyses in population-based studies of endometrial cancer risk." in: Cancer, Vol. 116, Issue 18, pp. 4275-82, 2010 (PubMed).

Ye, Lenain, Bauwens et al.: "TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage." in: Cell, Vol. 142, Issue 2, pp. 230-42, 2010 (PubMed).

Hosts (21), (11), (9)
Reactivities (38), (9), (5), (2), (2), (1)
Applications (36), (13), (12), (10), (9), (7), (4), (3), (2), (2), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1)
Epitopes (6), (2), (1), (1), (1), (1), (1)
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