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Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3) (AA 506-534), (C-Term) antibody

Details for Product No. ABIN657912, Supplier: Log in to see
Antigen
  • tcf3a
  • zgc:113045
  • E2A
  • E47
  • ITF1
  • TCF-3
  • VDIR
  • bHLHb21
  • A1
  • AA408400
  • ALF2
  • AW209082
  • E12
  • E12/E47
  • ME2
  • Pan1
  • Pan2
  • Tcfe2a
  • bhlhb21
  • e2a
  • itf1
  • tcfe2a
  • vdir
  • xtcf-3
  • xtcf3
  • G12
  • TCF7L1
  • Tcf3
Epitope
AA 506-534, C-Term
28
23
15
10
9
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
127
51
49
5
4
2
1
1
1
Host
Rabbit
92
19
18
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
4
4
4
3
3
3
3
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
98
72
54
22
13
12
3
2
2
Supplier
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Immunogen This TCF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 AA from the C-terminal region of human TCF3.
Clone RB33747
Isotype Ig
Specificity This TCF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 505-534 amino acids from the C-terminal region of human TCF3.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TCF3 (TCF3 Antibody Abstract)
Background The TCF3 gene, also called E2A, encodes 2 basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. E12 and E47 are involved in regulation of immunoglobulin gene expression (Bain et al., 1994 [PubMed 8001125]).
Synonyms: Transcription factor E2-alpha,6929,BHLHB21, E2A, ITF1
Molecular Weight 67600 DA
Gene ID 6929
NCBI Accession NP_001129611, NP_003191
UniProt P15923
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Chromatin, Signaling, Cell Structure
Pathways
Application Notes WB = 1:1000, FACS = 1:10-50, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.34 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TCF3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3) (AA 506-534), (C-Term) antibody (ABIN657912) TCF3 Antibody (C-term) (ABIN657912) western blot analysis in mouse cerebellum tissue ...
Background publications Hirose, Inukai, Kikuchi et al.: "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)." in: Blood, Vol. 116, Issue 6, pp. 962-70, 2010 (PubMed).

Pan, Yang, Chen et al.: "Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function." in: Immunogenetics, Vol. 62, Issue 4, pp. 237-51, 2010 (PubMed).

Rittié, Stoll, Kang et al.: "Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin." in: Aging cell, Vol. 8, Issue 6, pp. 738-51, 2009 (PubMed).

Hauser, Wallenius, Sveshnikova et al.: "Calmodulin inhibition of E2A stops expression of surrogate light chains of the pre-B-cell receptor and CD19." in: Molecular immunology, Vol. 47, Issue 5, pp. 1031-8, 2010 (PubMed).

Pedraza, Rafel, Navarro et al.: "Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways." in: The Journal of biological chemistry, Vol. 284, Issue 47, pp. 32980-8, 2009 (PubMed).