Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3) (C-Term), (AA 506-534) antibody

Details for Product No. ABIN657912
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Antigen
Synonyms tcf3a, zgc:113045, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21, A1, AA408400, ALF2, AW209082, E12, E12/E47, ME2, Pan1, Pan2, Tcfe2a, bhlhb21, e2a, itf1, tcfe2a, vdir, xtcf-3, xtcf3, G12, TCF7L1, Tcf3
Epitope
C-Term, AA 506-534
(22), (14), (12), (10), (7), (7), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(119), (72), (58), (26), (26), (25), (12), (2), (1)
Host
Rabbit
(94), (19), (7), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
(79), (60), (36), (30), (24), (17), (1)
Pubmed 5 references available
Quantity 400 µL
Options
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Catalog No. ABIN657912
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Immunogen This TCF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 AA from the C-terminal region of human TCF3.
Clone RB33747
Isotype Ig
Specificity This TCF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 505-534 amino acids from the C-terminal region of human TCF3.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TCF3
Background The TCF3 gene, also called E2A, encodes 2 basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. E12 and E47 are involved in regulation of immunoglobulin gene expression (Bain et al., 1994 [PubMed 8001125]).
Synonyms: Transcription factor E2-alpha,6929,BHLHB21, E2A, ITF1
Molecular Weight 67600 DA
Gene ID 6929
NCBI Accession NP_001129611, NP_003191
UniProt P15923
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.34 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TCF3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3) (C-Term), (AA 506-534) antibody TCF3 Antibody (C-term) (ABIN657912) western blot analysis in mouse cerebellum tissue lysates (35 µg/lane). This demonstrates the TCF3 antibody detected the TCF3 protein (arrow).
Background publications Pedraza, Rafel, Navarro et al.: "Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways." in: The Journal of biological chemistry, Vol. 284, Issue 47, pp. 32980-8, 2009 (PubMed).

Hauser, Wallenius, Sveshnikova et al.: "Calmodulin inhibition of E2A stops expression of surrogate light chains of the pre-B-cell receptor and CD19." in: Molecular immunology, Vol. 47, Issue 5, pp. 1031-8, 2010 (PubMed).

Rittié, Stoll, Kang et al.: "Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin." in: Aging cell, Vol. 8, Issue 6, pp. 738-51, 2009 (PubMed).

Pan, Yang, Chen et al.: "Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function." in: Immunogenetics, Vol. 62, Issue 4, pp. 237-51, 2010 (PubMed).

Hirose, Inukai, Kikuchi et al.: "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)." in: Blood, Vol. 116, Issue 6, pp. 962-70, 2010 (PubMed).

Validation Images
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