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HES1 (N-Term), (AA 3-32) antibody

Details for Product No. ABIN657944
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Antigen
Epitope
N-Term, AA 3-32
(16), (14), (7), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(77), (36), (36), (13), (13), (2), (1), (1), (1), (1)
Host
Rabbit
(49), (31), (3), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(72), (41), (23), (12), (12), (10), (6), (6), (5), (2), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN657944
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Immunogen This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 AA from the N-terminal region of human HES1.
Clone RB34029
Isotype Ig
Specificity This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HES1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Synonyms: Transcription factor HES-1,3280,BHLHB39, HL, HRY
Molecular Weight 29541 DA
Gene ID 3280
UniProt NP_005515.1, Q14469
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment HES1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-HES1 (N-Term), (AA 3-32) antibody HES1 Antibody (N-term) (ABIN657944) western blot analysis in U251 cell line lysates (35 µg/lane). This demonstrates the HES1 antibody detected the HES1 protein (arrow).
Background publications Sang, Roberts, Coller: "Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells." in: Trends in molecular medicine, Vol. 16, Issue 1, pp. 17-26, 2010 (PubMed).

Wang, Fu, Chen et al.: "The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study." in: Journal of cancer research and clinical oncology, Vol. 136, Issue 7, pp. 989-96, 2010 (PubMed).

Espinosa, Cathelin, DAltri et al.: "The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia." in: Cancer cell, Vol. 18, Issue 3, pp. 268-81, 2010 (PubMed).

Validation Images
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