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Details for Product No. ABIN657944

HES1 (N-Term), (AA 3-32) antibody

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Antigen
Synonyms HES-1, HHL, HRY, bHLHb39, Hry, HAIRY1, c-hairy1A
Epitope
»Alternatives N-Term, AA 3-32
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN657944
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 AA from the N-terminal region of human HES1.
Clone RB34029
Isotype Ig
Specificity This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HES1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Synonyms: Transcription factor HES-1,3280,BHLHB39, HL, HRY
Molecular Weight 29541 DA
Gene ID 3280
UniProt NP_005515.1, Q14469
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment HES1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Sang, Roberts, Coller: "Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells." in: Trends in molecular medicine, Vol. 16, Issue 1, pp. 17-26, 2010 (PubMed).

Wang, Fu, Chen et al.: "The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study." in: Journal of cancer research and clinical oncology, Vol. 136, Issue 7, pp. 989-96, 2010 (PubMed).

Espinosa, Cathelin, DAltri et al.: "The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia." in: Cancer cell, Vol. 18, Issue 3, pp. 268-81, 2010 (PubMed).

Alternatives for antigen "HES1", type "Antibodies"
Hosts (47), (31), (4), (1)
Reactivities (76), (36), (35), (14), (13), (3), (1), (1), (1), (1)
Applications (69), (38), (19), (13), (13), (10), (7), (4), (4), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (14), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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