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Details for Product No. ABIN657950

Retinoblastoma Binding Protein 8 (RBBP8) (C-Term), (AA 763-792) antibody

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Antigen
Synonyms COM1, CTIP, JWDS, RIM, SAE2, SCKL2, 9930104E21Rik, CtIP, RBBP-8, RGD1308872, RBBP8, DKFZp469K0714
Epitope
»Alternatives C-Term, AA 763-792
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN657950
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This RBBP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 763-792 AA from the C-terminal region of human RBBP8.
Clone RB34059
Isotype Ig
Specificity This RBBP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 762-792 amino acids from the C-terminal region of human RBBP8.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RBBP8
Background The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Synonyms: DNA endonuclease RBBP8,5932,CTIP
Molecular Weight 101942 DA
Gene ID 5932
UniProt NP_976037.1, NP_976036.1, NP_002885.1, Q99708
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Chromatin, Signaling, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment RBBP8 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Thye, Vannberg, Wong et al.: "Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2." in: Nature genetics, Vol. 42, Issue 9, pp. 739-41, 2010 (PubMed).

Kaidi, Weinert, Choudhary et al.: "Human SIRT6 promotes DNA end resection through CtIP deacetylation." in: Science (New York, N.Y.), Vol. 329, Issue 5997, pp. 1348-53, 2010 (PubMed).

Alternatives for antigen "Retinoblastoma Binding Protein 8 (RBBP8)", type "Antibodies"
Hosts (54), (3)
Reactivities (57), (30), (22), (12), (12), (1)
Applications (39), (29), (16), (13), (10), (5), (3), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (5), (5), (1), (1), (1), (1), (1), (1)
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