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Cancer Susceptibility Candidate 4 (CASC4) (AA 343-373), (C-Term) antibody

Details for Product No. ABIN951049, Supplier: Log in to see
Antigen
  • H63
  • D130060C09Rik
  • VGFG2573
Epitope
C-Term, AA 343-373
17
16
2
1
1
1
Reactivity
Human, Mouse (Murine)
23
5
1
Host
Rabbit
23
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
20
16
15
2
Supplier
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Immunogen KLH conjugated synthetic peptide between 343-373 amino acids from the C-terminal region of human CASC4
Isotype Ig
Specificity This antibody reacts to CASC4.
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Affinity chromatography on Protein A
Alternative Name CASC4 (CASC4 Antibody Abstract)
Background The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30 % of human breast and 20 % of human ovarian cancers. Further characterization of the product of this gene may yield insight into the fundamental biology and pathogenetic effects of HER-2/neu overexpression in human breast and ovarian cancer cells. Alternatively spliced variants encoding different isoforms have been identified for this gene.Synonyms: Cancer susceptibility candidate gene 4 protein
Molecular Weight 48864 Da
Gene ID 113201
NCBI Accession NP_612432
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Cancer Susceptibility Candidate 4 (CASC4) (AA 343-373), (C-Term) antibody (ABIN951049) CASC4 Antibody (C-term) western blot analysis in mouse Neuro-2a cell line lysat...
Background publications Lamesch, Li, Milstein et al.: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Sato, Peiper, Heinecke et al.: "Expression of HER2/neu does not correlate with survival in soft tissue sarcoma." in: Onkologie, Vol. 26, Issue 3, pp. 268-71, 2003 (PubMed).

Scheer, Prange, Petmecky et al.: "[Evaluation of her-2/neu amplification/overexpression in OSCC with fluorescence in situ hybridization (FISH) and immunohistochemistry]." in: Mund-, Kiefer- und Gesichtschirurgie : MKG, Vol. 7, Issue 3, pp. 138-45, 2003 (PubMed).