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Integrin, alpha 4 (Antigen CD49D, alpha 4 Subunit of VLA-4 Receptor) (ITGA4) antibody (PE)

Details for Product No. ABIN951338, Supplier: Login to see
Antigen
  • LOC100219853
  • CD49D
  • IA4
Reactivity
Mouse (Murine)
276
219
70
11
8
8
7
6
4
4
4
3
3
3
2
1
1
1
1
Host
Rat
215
194
74
Clonality (Clone)
Monoclonal ()
Conjugate
PE
86
69
33
9
6
4
4
4
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
384
129
91
73
52
34
32
30
24
18
12
6
4
3
3
3
2
2
2
2
2
2
1
Supplier
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Immunogen Peyers Patch HEV binding lymphoma line (TK1). Donor: Fisher Spleen. Fusion Partner: P3x63Ag8.653.
Clone R1-2
Isotype IgG2b
Specificity This CD49d Monoclonal Antibody reacts with Alpha-4 integrin (CD49d/ITGA4).
Purification Protein G Chromatography
Alternative Name CD49d / ITGA4 (ITGA4 Antibody Abstract)
Background CD49d helps to mediate cell-cell and cell-matrix interactions. Alpha-4 integrin combines with b1 and b7 integrin to form VLA-4 and LPAM-1 (Peyers patch homing receptor) respectively. VLA-4 is expressed on most peripheral lymphocytes, thymocytes and monocytes. LPAM-1 is found on peripheral lymphocytes, but few thymocytes. Fibronectin and VCAM-1 act as ligands for both VLA-4 and LPAM-1. LPAM-1 also binds the mucosal vascular addressin MAdCAM-1. (1)Synonyms: CD49 antigen-like family member D, Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4
Gene ID 16401
NCBI Accession NP_034706
UniProt Q00651
Research Area CD Antigens, Surface Receptors of Immune Cells, Cell/Tissue Markers, Extracellular Matrix, Signaling
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Berlin, Berg, Briskin et al.: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, 1993 (PubMed).

Holzmann, McIntyre, Weissman: "Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha." in: Cell, Vol. 56, Issue 1, pp. 37-46, 1989 (PubMed).