Integrin, alpha 4 (Antigen CD49D, alpha 4 Subunit of VLA-4 Receptor) (ITGA4) antibody (PE)

Details for Product No. ABIN951338
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Antigen
Synonyms LOC100219853, CD49D, IA4
Reactivity
Mouse (Murine)
(153), (121), (36), (6), (4), (4), (1), (1), (1), (1), (1)
Host
Rat
(105), (104), (45)
Clonality (Clone)
Monoclonal ()
Conjugate
PE
(45), (25), (24), (11), (2), (1), (1)
Application
Flow Cytometry (FACS)
(198), (70), (46), (45), (32), (25), (24), (20), (18), (14), (5), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 50 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN951338
253.00 $
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Immunogen Peyers Patch HEV binding lymphoma line (TK1). Donor: Fisher Spleen. Fusion Partner: P3x63Ag8.653.
Clone R1-2
Isotype IgG2b
Specificity This CD49d Monoclonal Antibody reacts with Alpha-4 integrin (CD49d/ITGA4).
Purification Protein G Chromatography
Alternative Name CD49d / ITGA4
Background CD49d helps to mediate cell-cell and cell-matrix interactions. Alpha-4 integrin combines with b1 and b7 integrin to form VLA-4 and LPAM-1 (Peyers patch homing receptor) respectively. VLA-4 is expressed on most peripheral lymphocytes, thymocytes and monocytes. LPAM-1 is found on peripheral lymphocytes, but few thymocytes. Fibronectin and VCAM-1 act as ligands for both VLA-4 and LPAM-1. LPAM-1 also binds the mucosal vascular addressin MAdCAM-1. (1)
Alternate names: CD49 antigen-like family member D, Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4
Gene ID 16401
NCBI Accession NP_034706
UniProt Q00651
Research Area CD Antigens, Surface Receptors of Immune Cells, Cell/Tissue Markers, Extracellular Matrix, Signaling
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Expiry Date 12 months
Background publications Holzmann, McIntyre, Weissman: "Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha." in: Cell, Vol. 56, Issue 1, pp. 37-46, 1989 (PubMed).

Berlin, Berg, Briskin et al.: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, 1993 (PubMed).

Validation Images
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