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CD8B antibody (Biotin)

CD8B Reactivity: Mouse FACS Host: Rat Monoclonal CT-CD8b Biotin
Catalog No. ABIN951402
  • Target See all CD8B Antibodies
    CD8B (CD8b Molecule (CD8B))
    Reactivity
    • 74
    • 31
    • 23
    • 13
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 77
    • 38
    • 21
    Rat
    Clonality
    • 78
    • 57
    • 1
    Monoclonal
    Conjugate
    • 58
    • 17
    • 15
    • 13
    • 8
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD8B antibody is conjugated to Biotin
    Application
    • 78
    • 71
    • 44
    • 22
    • 15
    • 14
    • 13
    • 13
    • 8
    • 7
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificity
    This anti-mouse CD8β Chain monoclonal antibody reacts with the mouse CD8 chain. The CD8 β Chain is also named Ly-3. The CD8 chain associates with the CD8 chain to form the CD8 / heterodimer on MHC class I restricted T-cells (cytotoxic T cells) and most thymocytes1. Since a small subset of T cells (IEL cells) express CD8 / homodimers rather than CD8 / heterodimers, investigators should use an antibody directed against the CD8 chain (CL168B, clone CT-CD8a) to definitively label mouse CD8 cells.
    Clone
    CT-CD8b
    Isotype
    IgG2a
    Top Product
    Discover our top product CD8B Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.1 % NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C. Should this product contain a precipitate we recommend microcentrifugation before use.
  • Target
    CD8B (CD8b Molecule (CD8B))
    Alternative Name
    CD8 beta (CD8B Products)
    Synonyms
    Cd8b antibody, Ly-3 antibody, Ly-C antibody, Lyt-3 antibody, CD8B1 antibody, LEU2 antibody, LY3 antibody, LYT3 antibody, P37 antibody, Cd8b1 antibody, CD8b molecule antibody, CD8 antigen, beta chain 1 antibody, Cd8b antibody, CD8B antibody, Cd8b1 antibody
    Background
    The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.Synonyms: CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain
    Gene ID
    12526
    NCBI Accession
    NP_033988
    UniProt
    P10300
    Pathways
    TCR Signaling
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