Cyclin C (CCNC) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN951753
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Antigen
Synonyms CG1C_DROME, CG7281, CYCC, Cln3, Cyc-C, DmcycC, Dmel\\CG7281, SRB11, cycC, cyclinC, dTRAP33, fj11d06, wu:fj11d06, zgc:73078, Cyclin-C, CycC, AI451004, AU020987, CG1C
Epitope
N-Term, AA 1-30
(9), (7), (6), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(54), (32), (32), (1), (1), (1)
Host
Rabbit
(52), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
(44), (26), (13), (10), (9), (8), (5), (5), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN951753
357.50 $
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Immunogen KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCNC
Isotype Ig
Specificity This antibody reacts to CCNC.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name Cyclin C
Background The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.Synonyms: CCNC, Cyclin-C, SRB11 homolog, hSRB11
Molecular Weight 33243 Da
Gene ID 892
NCBI Accession NP_005181
Research Area Chromatin and Nuclear Signaling, Cell Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Lamesch, Li, Milstein et al.: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Katona, Loyer, Roby et al.: "Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions." in: Acta biologica Hungarica, Vol. 58, Issue 1, pp. 133-7, 2007 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Makkonen, Malinen, Ropponen et al.: "Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene." in: Journal of molecular biology, Vol. 393, Issue 2, pp. 261-71, 2009 (PubMed).

Miyata, Liu, Jankovic et al.: "Cyclin C regulates human hematopoietic stem/progenitor cell quiescence." in: Stem cells (Dayton, Ohio), Vol. 28, Issue 2, pp. 308-17, 2010 (PubMed).

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