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Cytochrome B-245, alpha Polypeptide (CYBA) (AA 124-153), (C-Term) antibody

Details for Product No. ABIN951797, Supplier: Login to see
Antigen
  • zgc:66077
  • MGC80750
  • CYBA
  • p22-phox
  • p22phox
  • p22-PHOX
  • b558
  • nmf333
  • P22-PHOX
Epitope
C-Term, AA 124-153
17
15
13
3
2
2
2
1
Reactivity
Human
52
18
18
2
1
Host
Rabbit
43
9
Clonality
Polyclonal
Conjugate
Un-conjugated
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
33
19
16
11
6
5
4
4
2
2
Supplier
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Immunogen KLH conjugated synthetic peptide between 124-153 amino acids from the C-terminal region of Human Cytochrome b-245 light chain. Genename: CYBA
Isotype Ig
Specificity This antibody recognizes Human Cytochrome b-245 light chain (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name Cytochrome B-245 Light Chain (CYBA Antibody Abstract)
Background Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.Synonyms: CYBA, Cytochrome b(558) alpha chain, Cytochrome b558 subunit alpha, Neutrophil cytochrome b 22 kDa polypeptide, Superoxide-generating NADPH oxidase light chain subunit, p22 phagocyte B-cytochrome, p22-phox
Molecular Weight 21013 Da
Gene ID 1535
NCBI Accession NP_000092
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-Cytochrome B-245, alpha Polypeptide (CYBA) (AA 124-153), (C-Term) antibody (ABIN951797) Confocal immunofluorescent analysis of CYBA Antibody (C-term) Cat.-No AP51159PU-N wit...
Western Blotting (WB) image for anti-Cytochrome B-245, alpha Polypeptide (CYBA) (AA 124-153), (C-Term) antibody (ABIN951797) Western blot analysis of CYBA Antibody (C-term) Cat.-No AP51159PU-N in NCI-H292 cell ...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Katakami, Kaneto, Matsuoka et al.: "Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients." in: Atherosclerosis, Vol. 212, Issue 2, pp. 534-8, 2010 (PubMed).