Dual Oxidase 2 (DUOX2) (AA 520-550), (Middle Region) antibody

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Synonyms LNOX2, NOXEF2, P138-TOX, TDH6, THOX2, A430065P05Rik, Thox2
AA 520-550, Middle Region
(12), (12), (6), (2), (1)
(33), (19), (18), (6), (6)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
(25), (15), (10), (10), (4), (3), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 520-550 amino acids from the Central region of human DUOX2
Isotype Ig
Specificity This antibody recognizes Human Dual oxidase 2 (Center).
Purification Affinity Chromatography on Protein A
Alternative Name Dual Oxidase 2 (DUOX2 Antibody Abstract)
Background The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.Synonyms: LNOX2, Large NOX 2, Long NOX 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, NADPH thyroid oxidase 2, THOX2, Thyroid oxidase 2, p138 thyroid oxidase
Molecular Weight 175364 Da
Gene ID 50506
NCBI Accession NP_054799
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Dual Oxidase 2 (DUOX2) (AA 520-550), (Middle Region) antibody (ABIN951993) Flow cytometric analysis of CEM cells using Dual oxidase 2 Antibody Cat.-No AP51336PU...
Western Blotting (WB) image for anti-Dual Oxidase 2 (DUOX2) (AA 520-550), (Middle Region) antibody (ABIN951993) Western blot analysis of Dual oxidase 2 Antibody Cat.-No AP51336PU-N in CEM cell line...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Salmeen, Park, Meyer: "The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway." in: Oncogene, Vol. 29, Issue 31, pp. 4473-84, 2010 (PubMed).

Catalog No. ABIN951993
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