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Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C) (AA 126-155), (N-Term) antibody

Details for Product No. ABIN952048, Supplier: Log in to see
Antigen
  • eif3s8
  • fi37c04
  • zgc:66128
  • wu:fb34a08
  • wu:fi37c04
  • EIF3S8
  • EIF3CL
  • eif3-p110
  • LOC733086
  • eIF3c
  • eIF3-S8
  • AO090011000340
  • eIF3-p110
  • 110kDa
  • 3230401O13Rik
  • Eif3s8
  • NIPIL(A3)
  • NipilA3
  • Xs
  • Xsl
  • EIF3C
Epitope
AA 126-155, N-Term
16
13
11
8
7
2
2
2
1
1
1
1
1
1
Reactivity
Human
27
25
7
Host
Rabbit
43
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
38
27
8
7
4
3
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 126-155 amino acids from the N-terminal region of human EIF3CL
Isotype Ig
Specificity This antibody recognizes EIF3CL (N-term).
Cross-Reactivity (Details) Species reactivity (expected):Bovine, Mouse, Rat.
Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name EIF3C / EIF3S8 (EIF3C Antibody Abstract)
Background Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.Synonyms: Eukaryotic translation initiation factor 3 subunit 8, Eukaryotic translation initiation factor 3 subunit C, eIF3 p110
Molecular Weight 105344 Da
Gene ID 8663
NCBI Accession NP_001032897
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C) (AA 126-155), (N-Term) antibody (ABIN952048) Flow Cytometric analysis of K562 cells using EIF3CL Antibody (N-term) Cat.-No AP51396...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C) (AA 126-155), (N-Term) antibody (ABIN952048) Immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellu...
Western Blotting (WB) image for anti-Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C) (AA 126-155), (N-Term) antibody (ABIN952048) Western blot analysis using EIF3CL Antibody (N-term) Cat.-No AP51396PU-N in K562 cell...
Background publications Imielinski, Baldassano, Griffiths et al.: "Common variants at five new loci associated with early-onset inflammatory bowel disease." in: Nature genetics, Vol. 41, Issue 12, pp. 1335-40, 2009 (PubMed).

Zhou, Sandercock, Fraser et al.: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, 2008 (PubMed).

Masutani, Sonenberg, Yokoyama et al.: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, 2007 (PubMed).

Damoc, Fraser, Zhou et al.: "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 7, pp. 1135-46, 2007 (PubMed).

Sugiyama, Masuda, Shinoda et al.: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).