anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788)

Details for Product anti-IL12RB2 Antibody No. ABIN952881
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Synonyms IL12RB2, A930027I18Rik, IL-12RB2, Ifnm
AA 759-788, C-Term
(15), (14), (12), (6), (5), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
(61), (26), (14)
(60), (13)
This IL12RB2 antibody is un-conjugated
(8), (6), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(50), (36), (19), (18), (12), (10), (7), (7), (3), (1)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 759-788aa) of human IL12RB2.
Isotype Ig
Specificity This antibody detects human IL12RB2 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a protein A column; followed by peptide affinity purification.
Alternative Name IL12RB2 (IL12RB2 Antibody Abstract)
Background The protein encoded by the IL12RB2 gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.Synonyms: IL-12 receptor beta-2, IL-12R-beta-2, Interleukin-12 receptor beta-2 chain
Gene ID 3595
NCBI Accession NP_001550
Research Area Cancer, Cytokines, Innate Immunity
Pathways JAK-STAT Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788) (ABIN952881) Flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788) (ABIN952881) Immunohistochemistry analysis in human tonsils tissue (formalin-fixed, paraffin-embed...
Western Blotting (WB) image for anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788) (ABIN952881) Western blot analysis in MDA-MB435 cell line lysates (35ug/lane) using IL12RB2 antibo...
Background publications Liu, Invernizzi, Lu et al.: "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis...." in: Nature genetics, Vol. 42, Issue 8, pp. 658-60, 2010 (PubMed).

Mizuki, Meguro, Ota et al.: "Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci." in: Nature genetics, Vol. 42, Issue 8, pp. 703-6, 2010 (PubMed).

Remmers, Cosan, Kirino et al.: "Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease." in: Nature genetics, Vol. 42, Issue 8, pp. 698-702, 2010 (PubMed).

Catalog No. ABIN952881
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