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IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788)

Details for Product anti-IL12RB2 Antibody No. ABIN952881, Supplier: Log in to see
Antigen
  • IL12RB2
  • A930027I18Rik
  • IL-12RB2
  • Ifnm
Alternatives
anti-Human IL12RB2 antibody for Western Blotting
Epitope
AA 759-788, C-Term
16
13
10
7
7
5
5
4
3
3
2
2
2
1
1
1
1
Reactivity
Human
63
27
15
Host
Rabbit
61
14
Clonality
Polyclonal
Conjugate
This IL12RB2 antibody is un-conjugated
7
6
4
4
3
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
47
36
19
17
11
10
4
4
1
1
Supplier
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 759-788aa) of human IL12RB2.
Isotype Ig
Specificity This antibody detects human IL12RB2 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a protein A column; followed by peptide affinity purification.
Alternative Name IL12RB2 (IL12RB2 Antibody Abstract)
Background The protein encoded by the IL12RB2 gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.Synonyms: IL-12 receptor beta-2, IL-12R-beta-2, Interleukin-12 receptor beta-2 chain
Gene ID 3595
NCBI Accession NP_001550
Research Area Cancer, Cytokines, Innate Immunity
Pathways JAK-STAT Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788) (ABIN952881) Flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788) (ABIN952881) Immunohistochemistry analysis in human tonsils tissue (formalin-fixed, paraffin-embed...
Western Blotting (WB) image for anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788) (ABIN952881) Western blot analysis in MDA-MB435 cell line lysates (35ug/lane) using IL12RB2  Antib...
Background publications Liu, Invernizzi, Lu et al.: "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis...." in: Nature genetics, Vol. 42, Issue 8, pp. 658-60, 2010 (PubMed).

Mizuki, Meguro, Ota et al.: "Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci." in: Nature genetics, Vol. 42, Issue 8, pp. 703-6, 2010 (PubMed).

Remmers, Cosan, Kirino et al.: "Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease." in: Nature genetics, Vol. 42, Issue 8, pp. 698-702, 2010 (PubMed).