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Details for Product No. ABIN952881

Interleukin 12 Receptor, beta 2 (IL12RB2) (C-Term), (AA 759-788) antibody

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Antigen
Synonyms Ifnm, IL-12RB2, A930027I18Rik, IL12RB2
Epitope
»Alternatives C-Term, AA 759-788
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN952881
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 759-788aa) of human IL12RB2.
Specificity This antibody detects human IL12RB2 at C-term.
Purification Purified through a protein A column; followed by peptide affinity purification.
Alternative Name IL12RB2
Background The protein encoded by the IL12RB2 gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Alternate names: IL-12 receptor beta-2, IL-12R-beta-2, Interleukin-12 receptor beta-2 chain
Gene ID 3595
NCBI Accession NP_001550
Research Area Cancer, Cytokines, Innate Immunity
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Remmers, Cosan, Kirino et al.: "Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease." in: Nature genetics, Vol. 42, Issue 8, pp. 698-702, 2010 (PubMed).

Mizuki, Meguro, Ota et al.: "Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci." in: Nature genetics, Vol. 42, Issue 8, pp. 703-6, 2010 (PubMed).

Liu, Invernizzi, Lu et al.: "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis." in: Nature genetics, Vol. 42, Issue 8, pp. 658-60, 2010 (PubMed).

Alternatives for antigen "Interleukin 12 Receptor, beta 2 (IL12RB2)", type "Antibodies"
Hosts (27), (7)
Reactivities (34), (17), (17), (17), (17), (17)
Applications (19), (17), (10), (10), (6), (4), (2), (2), (2)
Conjugates (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (2), (1), (1), (1)
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