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Interleukin 12 Receptor, beta 2 (IL12RB2) (C-Term), (AA 759-788) antibody

Details for Product No. ABIN952881
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Antigen
Synonyms Ifnm, IL-12RB2, A930027I18Rik, IL12RB2
Epitope
C-Term, AA 759-788
(8), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(41), (19), (17), (17), (17), (17)
Host
Rabbit
(36), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(26), (25), (19), (14), (9), (9), (5), (5), (2)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN952881
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 759-788aa) of human IL12RB2.
Specificity This antibody detects human IL12RB2 at C-term.
Purification Purified through a protein A column; followed by peptide affinity purification.
Alternative Name IL12RB2
Background The protein encoded by the IL12RB2 gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Alternate names: IL-12 receptor beta-2, IL-12R-beta-2, Interleukin-12 receptor beta-2 chain
Gene ID 3595
NCBI Accession NP_001550
Research Area Cancer, Cytokines, Innate Immunity
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Remmers, Cosan, Kirino et al.: "Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease." in: Nature genetics, Vol. 42, Issue 8, pp. 698-702, 2010 (PubMed).

Mizuki, Meguro, Ota et al.: "Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci." in: Nature genetics, Vol. 42, Issue 8, pp. 703-6, 2010 (PubMed).

Liu, Invernizzi, Lu et al.: "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis...." in: Nature genetics, Vol. 42, Issue 8, pp. 658-60, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN952881
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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