Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 247-276), (Middle Region) antibody

Details for Product No. ABIN953114
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Antigen
Synonyms krm2, KREMEN2, MGC147633, KRM2, 2900054E04Rik, Krm2
Epitope
AA 247-276, Middle Region
(7), (7), (2), (2), (1), (1), (1)
Reactivity
Human
(14)
Host
Rabbit
(11), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(14), (8), (2), (1)
Pubmed 1 reference available
Quantity 0.4 mL
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Catalog No. ABIN953114
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Immunogen KLH conjugated synthetic peptide between 247-276 amino acids from the Central region of human KREMEN2
Isotype Ig
Specificity This antibody reacts to KREMEN2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name Kremen Protein 2
Background This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.Synonyms: Dickkopf receptor 2, KREMEN2, KRM2, Kringle domain-containing transmembrane protein 2, Kringle-containing protein marking the eye and the nose
Gene ID 79412
NCBI Accession NP_078783
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Mao, Wu, Davidson et al.: "Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling." in: Nature, Vol. 417, Issue 6889, pp. 664-7, 2002 (PubMed).

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