KREMEN2 antibody (AA 248-276)

Catalog No. ABIN656978

Product Details anti-KREMEN2 Antibody

Target: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Binding Specificity: AA 248-276

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KREMEN2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KREMEN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-276 amino acids from the Central region of human KREMEN2.

Clone: RB32950

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: KREMEN2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for KREMEN2

Target: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Alternative Name: KREMEN2 (KREMEN2 Products)

Synonyms: krm2 antibody, KREMEN2 antibody, MGC147633 antibody, KRM2 antibody, 2900054E04Rik antibody, Krm2 antibody, kringle containing transmembrane protein 2 S homeolog antibody, kringle containing transmembrane protein 2 antibody, kremen2.S antibody, KREMEN2 antibody, kremen2 antibody, Kremen2 antibody

Background: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Molecular Weight: 48849

Gene ID: 79412

NCBI Accession: NP_001240654, NP_001240655, NP_078783, NP_757384

UniProt: Q8NCW0

Pathways: WNT Signaling