Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2) (AA 56-83), (Middle Region) antibody

Details for Product No. ABIN953745
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Antigen
Synonyms SHP, SHP1, SHP-1, Shp1, Shp, NR0B2-A, Nr0b2, SHP-A, gb:bc058069
Epitope
AA 56-83, Middle Region
(9), (8), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(55), (16), (14), (13), (13), (1)
Host
Rabbit
(47), (5), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(37), (19), (16), (15), (14), (10), (8), (7), (2), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN953745
357.50 $
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Immunogen KLH conjugated synthetic peptide between 56-83 amino acids from the Central region of human NR0B2
Isotype Ig
Specificity This antibody reacts to NR0B2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name NR0B2
Background The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.Synonyms: Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, SHP, Small heterodimer partner
Molecular Weight 28058 Da
Gene ID 8431
NCBI Accession NP_068804
Research Area Signaling, Metabolism, Receptors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Ondracek, Rushing, Reese et al.: "Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis." in: Journal of virology, Vol. 83, Issue 23, pp. 12535-44, 2009 (PubMed).

Kim, Kim, Cho et al.: "SHP (small heterodimer partner) suppresses the transcriptional activity and nuclear localization of Hedgehog signalling protein Gli1." in: The Biochemical journal, Vol. 427, Issue 3, pp. 413-22, 2010 (PubMed).

Yang, Wu, Zheng et al.: "Gender-dependent penetrance of small heterodimer partner (SHP) gene deficiency in overweight/obese Chinese pedigrees." in: The Journal of international medical research, Vol. 38, Issue 1, pp. 142-9, 2010 (PubMed).

Roberts, Kawut, Krowka et al.: "Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease." in: Gastroenterology, Vol. 139, Issue 1, pp. 130-9.e24, 2010 (PubMed).

Zhou, Zhang, Macchiarulo et al.: "Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24871-81, 2010 (PubMed).

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