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Phosphatidylinositol Glycan Anchor Biosynthesis, Class V (PIGV) (AA 342-371), (C-Term) antibody

Details for Product No. ABIN954140, Supplier: Log in to see
Antigen
  • GPI-MT-II
  • HPMRS1
  • PIG-V
  • B330013B03
  • D430024F16Rik
  • RGD1309526
Epitope
C-Term, AA 342-371
16
15
3
2
Reactivity
Human
22
3
3
3
1
Host
Rabbit
22
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
20
15
4
Supplier
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 342-371aa) of human PIGV.
Isotype Ig
Specificity This antibody recognizes PIGV at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name PIGV (PIGV Antibody Abstract)
Background Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. The biosynthetic pathway of GPI is mediated by sequential addition of sugars and other components to phosphatidylinositol. PIGV adds the second mannose to the GPI core [Kang et al., 2005 PubMed 15623507].Synonyms: GPI mannosyltransferase 2, GPI-MT-II, PIG-V, Phosphatidylinositol-glycan biosynthesis class V protein
Gene ID 55650
NCBI Accession NP_001189483
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Phosphatidylinositol Glycan Anchor Biosynthesis, Class V (PIGV) (AA 342-371), (C-Term) antibody (ABIN954140) Western blot analysis in WiDr cell line lysates (35ug/lane) using PIGV  Antibody (C-t...
Background publications Krawitz, Schweiger, Rödelsperger et al.: "Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome." in: Nature genetics, Vol. 42, Issue 10, pp. 827-9, 2010 (PubMed).

Fabre, Orlean, Taron: "Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly." in: The FEBS journal, Vol. 272, Issue 5, pp. 1160-8, 2005 (PubMed).

Kang, Hong, Ashida et al.: "PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol." in: The Journal of biological chemistry, Vol. 280, Issue 10, pp. 9489-97, 2005 (PubMed).

Kinoshita, Inoue: "Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis." in: Current opinion in chemical biology, Vol. 4, Issue 6, pp. 632-8, 2001 (PubMed).