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Phosphatidylinositol Glycan Anchor Biosynthesis, Class V (PIGV) (C-Term), (AA 342-371) antibody

Details for Product No. ABIN954140
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Antigen
Synonyms GPI-MT-II, HPMRS1, PIG-V, B330013B03, D430024F16Rik, RGD1309526
Epitope
C-Term, AA 342-371
(2), (1)
Reactivity
Human
(3), (1), (1), (1), (1)
Host
Rabbit
(4)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(4), (3)
Pubmed 4 references available
Catalog no. ABIN954140
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 342-371aa) of human PIGV.
Specificity This antibody recognizes PIGV at C-term.
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name PIGV
Background Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. The biosynthetic pathway of GPI is mediated by sequential addition of sugars and other components to phosphatidylinositol. PIGV adds the second mannose to the GPI core [Kang et al., 2005 PubMed 15623507].
Alternate names: GPI mannosyltransferase 2, GPI-MT-II, PIG-V, Phosphatidylinositol-glycan biosynthesis class V protein
Gene ID 55650
NCBI Accession NP_001189483
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Kinoshita, Inoue: "Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis." in: Current opinion in chemical biology, Vol. 4, Issue 6, pp. 632-8, 2001 (PubMed).

Kang, Hong, Ashida et al.: "PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol." in: The Journal of biological chemistry, Vol. 280, Issue 10, pp. 9489-97, 2005 (PubMed).

Fabre, Orlean, Taron: "Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly." in: The FEBS journal, Vol. 272, Issue 5, pp. 1160-8, 2005 (PubMed).

Krawitz, Schweiger, Rödelsperger et al.: "Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome." in: Nature genetics, Vol. 42, Issue 10, pp. 827-9, 2010 (PubMed).

Hosts (4)
Reactivities (3), (1), (1), (1), (1)
Applications (4), (3)
Epitopes (2), (1)
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