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Apolipoprotein A-V (APOA5) (N-Term) antibody

Details for Product No. ABIN965570
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Antigen
Synonyms APOA5, MGC140487, rap3, apoav, apoa-v, APOAV, RAP3, apo-AV, apoA-V, 1300007O05Rik, Apoav
Epitope
N-Term
(12), (11), (3), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(98), (13), (13), (12), (8), (1)
Host
Rabbit
(59), (40), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(78), (77), (11), (10), (9), (5), (4), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN965570
371.25 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human APOA5 (Apolipoprotein A-V precursor)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name APOA5
Background APOA5(Apolipoprotein A-V) is a minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. APOA5 may also be associated with chylomicrons. APOA5 is an important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDLTG production rate (without affecting the VLDL-apoB production rate). Three common alleles are known: allele APOA5*1, APOA5*2 and APOA5*3. The APOA5*2 haplotype, which consists of 3 non-coding SNPs, is present in approximately 16% of Caucasians and is associated with increased plasma triglyceride concentrations. APOA5*3 haplotype is defined by the rare Ser-19-Trp substitution. Together, the APOA5*2 and APOA5*3 haplotypes are found in 25 to 50% of African Americans, Hispanics, and Caucasians.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: van der Vliet, Sammels, Leegwater et al.: "Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 44512-20, 2001 (PubMed).

Pennacchio, Olivier, Hubacek et al.: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, 2001 (PubMed).

Prieur, Coste, Rodriguez: "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25468-80, 2003 (PubMed).

Weinberg, Cook, Beckstead et al.: "Structure and interfacial properties of human apolipoprotein A-V." in: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 34438-44, 2003 (PubMed).

Fullerton, Buchanan, Sonpar et al.: "The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster." in: Human genetics, Vol. 115, Issue 1, pp. 36-56, 2004 (PubMed).

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