Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (N-Term) antibody

Antigen: Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G)

Synonyms: ARP9, CEM15, MDS019, FLJ12740, bK150C2.7, dJ494G10.1, APOBEC3G

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN965574

Additional Information

Alternative name: APOBEC3G

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human APOBEC3G (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G)

Description: APOBEC3G (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G) is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. APOBEC3G is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. APOBEC3G has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.

Application Details

Research Area: Immunology, Chromatin Binding Proteins

Restrictions: For Research Use only

Publications

Product: Kamada, Igarashi, Martin et al.: "Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 45, pp. 16959-64, 2006 (PubMed).

Vetter, DAquila: "Cytoplasmic APOBEC3G restricts incoming Vif-positive human immunodeficiency virus type 1 and increases two-long terminal repeat circle formation in activated T-helper-subtype cells." in: Journal of virology, Vol. 83, Issue 17, pp. 8646-54, 2009 (PubMed).

Dang, Wang, Zhou et al.: "Identification of a novel WxSLVK motif in the N terminus of human immunodeficiency virus and simian immunodeficiency virus Vif that is critical for APOBEC3G and APOBEC3F neutralization." in: Journal of virology, Vol. 83, Issue 17, pp. 8544-52, 2009 (PubMed).

Chen, He, Wang et al.: "A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G." in: Journal of virology, Vol. 83, Issue 17, pp. 8674-82, 2009 (PubMed).

Pido-Lopez, Jeffrey, Wang et al.: "The effect of allogeneic in vitro stimulation and in vivo immunization on memory CD4(+) T-cell APOBEC3G expression and HIV-1 infectivity." in: European journal of immunology, Vol. 39, Issue 7, pp. 1956-65, 2009 (PubMed).