Caspase Recruitment Domain Family, Member 9 (CARD9) (N-Term) antibody

Antigen: Caspase Recruitment Domain Family, Member 9 (CARD9)

Synonyms: hCARD9, card9, Gm782, RP23-306D20.2, CARD9

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN965748

Additional Information

Alternative name: CARD9

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human CARD9(Caspase recruitment domain-containing protein 9)

Description: CARD9(Caspase recruitment domain-containing protein 9) is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Three alternatively spliced variants of this gene encoding distinct isoforms have been reported.

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Purification: Purified by antigen-specific affinity chromatography.

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: 0.01% Sodium Azide

Storage: Store at -20°C.

Research Area: Apoptosis/Necrosis

Restrictions: For Research Use only

Publications

Product: Bertin, Guo, Wang et al.: "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41082-6, 2001 (PubMed).

Wang, Guo, Huang et al.: "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21405-9, 2001 (PubMed).