CARD9 antibody

Catalog No. ABIN499537

This Rabbit Polyclonal antibody specifically detects CARD9 in WB, IF and EIA. It exhibits reactivity toward Human.

Quick Overview for CARD9 antibody (ABIN499537)

Target: CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CARD9 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-CARD9 Antibody

Specificity: CARD9 antibody was raised against a synthetic peptide corresponding to amino acids 521 to 536 of human CARD9 The sequence is different from that of rat origin by two amino acids.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human CARD9 Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CARD9 antibody can be used for detection of CARD9 at 0.5 to 1 μg/mL. A bandat approximately 59 kDa can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CARD9

Target: CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

Alternative Name: CARD9

Background: Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD9, which interacts with the CARD activation domain of BCL-10 (1). CARD9 associates with BCL-10 and forms a complex within cells. CARD9 induces apoptosis and activates NF-kappaB. CARD9 is an upstream activator of BCL-10 and NF-kappaB signaling.Synonyms: Caspase recruitment domain-containing protein 9

Gene ID: 64170

NCBI Accession: NP_434700

UniProt: Q9H257

Pathways: Activation of Innate immune Response