CD80 (CD80) (N-Term), (AA 57-71) antibody

Details for Product No. ABIN965820
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Antigen
Synonyms CD8, Leu2, MAL, p32, B71, Cd28l, Ly-53, Ly53, MIC17, TSA1, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Epitope
N-Term, AA 57-71
(10), (10), (7), (6), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(198), (156), (32), (4), (4), (3), (2), (1)
Host
Please enquire
(167), (80), (75), (51), (6), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(42), (39), (37), (13), (7), (6), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(244), (94), (74), (55), (30), (28), (24), (24), (22), (20), (8), (2), (2), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µg
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Catalog No. ABIN965820
316.25 $
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human CD80 (57-71aa), identical to the related mouse and rat sequence.
Alternative Name CD80
Background Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al. (1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes WB: The detection limit for CD80/ B7-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Peach, Bajorath, Naemura et al.: "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28." in: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 21181-7, 1995 (PubMed).

Stamper, Zhang, Tobin et al.: "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses." in: Nature, Vol. 410, Issue 6828, pp. 608-11, 2001 (PubMed).

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