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Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) (AA 1339-1351) antibody

Details for Product No. ABIN965878, Supplier: Login to see
Antigen
  • CFTR
  • AW495489
  • Abcc7
  • RGD1561193
  • ABC35
  • ABCC7
  • CF
  • CFTR/MRP
  • MRP7
  • TNR-CFTR
  • dJ760C5.1
  • abc35
  • abcc7
  • cftr/mrp
  • mrp7
  • tnr-cftr
  • xcftr
Epitope
AA 1339-1351
12
4
4
4
4
4
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Sheep (Ovine)
74
24
19
3
2
2
2
1
Host
Rabbit
43
27
5
Clonality
Polyclonal
Conjugate
Un-conjugated
1
Application
Immunohistochemistry (IHC)
54
26
24
22
21
18
4
4
3
3
2
2
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to residues 1339-1351 of human CFTR (Cystic fibrosis transmembrane conductance regulator)
Alternative Name CFTR (CFTR Antibody Abstract)
Background CFTR (Cystic fibrosis transmembrane conductance regulator) is involved in the transport of chloride ions and binds SLC9A3R1. CFTR is an integral membrane protein. Defects in CFTR are the cause of cystic fibrosis (CF) , also known as mucoviscidosis. It belongs to the ABC transporter family and MRP subfamily.
Pathways
Restrictions For Research Use only
Storage -20 °C
Background publications Karthikeyan, Leung, Ladias: "Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator." in: The Journal of biological chemistry, Vol. 276, Issue 23, pp. 19683-6, 2001 (PubMed).

Hoedemaeker, Davidson, Rose: "A model for the nucleotide-binding domains of ABC transporters based on the large domain of aspartate aminotransferase." in: Proteins, Vol. 30, Issue 3, pp. 275-86, 1998 (PubMed).

Neville, Rozanas, Price et al.: "Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry." in: Protein science : a publication of the Protein Society, Vol. 6, Issue 11, pp. 2436-45, 1998 (PubMed).

Riordan, Rommens, Kerem et al.: "Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA." in: Science (New York, N.Y.), Vol. 245, Issue 4922, pp. 1066-73, 1989 (PubMed).

Zielenski, Rozmahel, Bozon et al.: "Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene." in: Genomics, Vol. 10, Issue 1, pp. 214-28, 1991 (PubMed).

Cutting, Kasch, Rosenstein et al.: "A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein." in: Nature, Vol. 346, Issue 6282, pp. 366-9, 1990 (PubMed).

Picciotto, Cohn, Bertuzzi et al.: "Phosphorylation of the cystic fibrosis transmembrane conductance regulator." in: The Journal of biological chemistry, Vol. 267, Issue 18, pp. 12742-52, 1992 (PubMed).

Tsui: "Mutations and sequence variations detected in the cystic fibrosis transmembrane conductance regulator (CFTR) gene: a report from the Cystic Fibrosis Genetic Analysis Consortium." in: Human mutation, Vol. 1, Issue 3, pp. 197-203, 1993 (PubMed).