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CFTR Products

(Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008].

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Featured CFTR Categories

CFTR Antibodies

High quality antibodies with extensive validation data.

CFTR ELISA Kits

Reliable ELISA kits for a wide range of species.

CFTR Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CFTR Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application FACS, IHC (f)
Validations
  • (3)
Cat. No. ABIN6939092
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC (f)
Validations
  • (2)
Cat. No. ABIN7126143
Quantity 20 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
  • (2)
Cat. No. ABIN3183888
Quantity 100 μL
Datasheet Datasheet

Recommended CFTR ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966205
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962401
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955205
Quantity 96 tests
Datasheet Datasheet

Recommended CFTR Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (3)
Cat. No. ABIN3091166
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3133471
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3091165
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CFTR products

Ye, Onodera, Blanchard, Kusminski, Esser, Brekken, Scherer: "β1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis." in: The American journal of pathology, Vol. 189, Issue 4, pp. 813-825, (2019) (PubMed).

Romani, Oikonomou, Moretti, Iannitti, DAdamo, Villella, Pariano, Sforna, Borghi, Bellet, Fallarino, Pallotta, Servillo, Ferrari, Puccetti, Kroemer, Pessia, Maiuri, Goldstein, Garaci: "Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis." in: Nature medicine, Vol. 23, Issue 5, pp. 590-600, (2017) (PubMed).

Xu, Yong, Li, Dong, Yu, Fu, Hu: "High level of CFTR expression is associated with tumor aggression and knockdown of CFTR suppresses proliferation of ovarian cancer in vitro and in vivo." in: Oncology reports, Vol. 33, Issue 5, pp. 2227-34, (2015) (PubMed).

Rottner, Kunzelmann, Mergey, Freyssinet, Martínez: "Exaggerated apoptosis and NF-kappaB activation in pancreatic and tracheal cystic fibrosis cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 21, Issue 11, pp. 2939-48, (2007) (PubMed).

Di, Brown, Deriy, Li, Szeto, Chen, Huang, Tong, Naren, Bindokas, Palfrey, Nelson: "CFTR regulates phagosome acidification in macrophages and alters bactericidal activity." in: Nature cell biology, Vol. 8, Issue 9, pp. 933-44, (2006) (PubMed).

Benlloch, Ortega, Ferrer, Segarra, Obrador, Asensi, Carretero, Estrela: "Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 6950-9, (2005) (PubMed).

Kulka, Dery, Nahirney, Duszyk, Befus: "Differential regulation of cystic fibrosis transmembrane conductance regulator by interferon gamma in mast cells and epithelial cells." in: The Journal of pharmacology and experimental therapeutics, Vol. 315, Issue 2, pp. 563-70, (2005) (PubMed).

Laverty, McWilliams, Sheldon, Arnason: "PTH stimulates a Cl(-)-dependent and EIPA-sensitive current in chick proximal tubule cells in culture." in: American journal of physiology. Renal physiology, Vol. 284, Issue 5, pp. F987-95, (2003) (PubMed).

Dalby-Payne, OLoughlin, Gunning: "Polarization of specific tropomyosin isoforms in gastrointestinal epithelial cells and their impact on CFTR at the apical surface." in: Molecular biology of the cell, Vol. 14, Issue 11, pp. 4365-75, (2003) (PubMed).

Kulka, Gilchrist, Duszyk, Befus: "Expression and functional characterization of CFTR in mast cells." in: Journal of leukocyte biology, Vol. 71, Issue 1, pp. 54-64, (2002) (PubMed).

Synonyms and alternative names related to CFTR

cystic fibrosis transmembrane conductance regulator (CFTR), cystic fibrosis transmembrane conductance regulator (cftr-A), cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR), cystic fibrosis transmembrane conductance regulator (Cftr), cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (cftr), ABC35, abc35, ABCC7, Abcc7, abcc7, AW495489, CF, CFTR, CFTR/MRP, cftr/mrp, dJ760C5.1, MRP7, mrp7, RGD1561193, si:dkey-270i2.2, TNR-CFTR, tnr-cftr, xcftr

Protein level used designations for CFTR

  • cAMP-dependent chloride channel
  • channel conductance-controlling ATPase
  • cystic fibrosis transmembrane conductance regulator
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
  • cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
  • ATP-binding cassette sub-family C member 7
  • ATP-binding cassette transporter sub-family C member 7
  • ATP-binding cassette, subfamily c, member 7
  • cystic fibrosis transmembrane conductance regulator homolog
  • cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7
  • CFTR chloride channel
  • chloride channel
  • CFTR cAMP-dependent chloride channel protein
  • Channel conductance-controlling ATPase
  • abcc7
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