Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) (N-Term) antibody

Antigen: Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3)

Synonyms: LOC574143, DAT, SLC6A3

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN965973

Additional Information

Alternative name: DAT

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DAT(Sodium-dependent dopamine transporter)

Description: DAT(Sodium-dependent dopamine transporter)is an amine transporter. DAT terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. This protein is the target of psychomotor stimulants such as amphetamines or cocaine. It belongs to the sodium: neurotransmitter symporter (SNF) family.

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Purification: Purified by antigen-specific affinity chromatography.

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: 0.01% Sodium Azide

Storage: Store at -20°C.

Restrictions: For Research Use only

Publications

Product: Vandenbergh, Persico, Uhl: "A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs." in: Brain research. Molecular brain research, Vol. 15, Issue 1-2, pp. 161-6, 1992 (PubMed).

Donovan, Vandenbergh, Perry et al.: "Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures." in: Brain research. Molecular brain research, Vol. 30, Issue 2, pp. 327-35, 1995 (PubMed).

Pristupa, Wilson, Hoffman et al.: "Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding." in: Molecular pharmacology, Vol. 45, Issue 1, pp. 125-35, 1994 (PubMed).

Vandenbergh, Thompson, Cook et al.: "Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations." in: Molecular psychiatry, Vol. 5, Issue 3, pp. 283-92, 2000 (PubMed).

Greenwood, Alexander, Keck et al.: "Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder." in: American journal of medical genetics, Vol. 105, Issue 2, pp. 145-51, 2001 (PubMed).

Torres, Yao, Mohn et al.: "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1." in: Neuron, Vol. 30, Issue 1, pp. 121-34, 2001 (PubMed).