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Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) (N-Term) antibody

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Synonyms DAT, SLC6A3, Dat1, DAT1, PKDYS
(28), (14), (7), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1)
(65), (25), (24), (2), (2)
(53), (13), (6), (1)
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC)
(55), (29), (15), (11), (10), (8), (3), (3), (2), (1), (1)
Pubmed 6 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DAT(Sodium-dependent dopamine transporter)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name DAT (SLC6A3 Antibody Abstract)
Background DAT(Sodium-dependent dopamine transporter)is an amine transporter. DAT terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. This protein is the target of psychomotor stimulants such as amphetamines or cocaine. It belongs to the sodium: neurotransmitter symporter (SNF) family.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Pristupa, Wilson, Hoffman et al.: "Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding." in: Molecular pharmacology, Vol. 45, Issue 1, pp. 125-35, 1994 (PubMed).

Vandenbergh, Persico, Uhl: "A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs." in: Brain research. Molecular brain research, Vol. 15, Issue 1-2, pp. 161-6, 1992 (PubMed).

Background publications Torres, Yao, Mohn et al.: "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1." in: Neuron, Vol. 30, Issue 1, pp. 121-34, 2001 (PubMed).

Greenwood, Alexander, Keck et al.: "Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder." in: American journal of medical genetics, Vol. 105, Issue 2, pp. 145-51, 2001 (PubMed).

Vandenbergh, Thompson, Cook et al.: "Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations." in: Molecular psychiatry, Vol. 5, Issue 3, pp. 283-92, 2000 (PubMed).

Donovan, Vandenbergh, Perry et al.: "Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures." in: Brain research. Molecular brain research, Vol. 30, Issue 2, pp. 327-35, 1995 (PubMed).

Catalog No. ABIN965973
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