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IGF1R antibody

IGF1R Reactivity: Human WB, ELISA, IHC Monoclonal unconjugated
Catalog No. ABIN966348
  • Target See all IGF1R Antibodies
    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
    Reactivity
    • 188
    • 110
    • 93
    • 16
    • 8
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    Please inquire
    Clonality
    • 175
    • 30
    Monoclonal
    Conjugate
    • 126
    • 8
    • 8
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    This IGF1R antibody is un-conjugated
    Application
    • 131
    • 71
    • 61
    • 59
    • 33
    • 25
    • 18
    • 13
    • 13
    • 11
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    Crude ascites.
    Immunogen
    Ni-NTA purified truncated recombinant IGF1R-His expressed in E. Coli strain BL21 (DE3)
    Isotype
    IgG2b
    Top Product
    Discover our top product IGF1R Primary Antibody
  • Application Notes
    Western Blot: 1: 500- 1: 2,000
    IHC(P): 1: 500- 1: 2,000
    IHC(F): 1: 500- 1: 2,000
    ELISA: Propose dilution 1: 10,000.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Storage
    -20 °C
  • Scheidegger, Cenni, Picard, Delafontaine: "Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects." in: The Journal of biological chemistry, Vol. 275, Issue 49, pp. 38921-8, (2001) (PubMed).

    Fujimoto, Tomita, Wakamatsu, Tanimoto, Ike: "Physical mapping of the conjugative bacteriocin plasmid pPD1 of Enterococcus faecalis and identification of the determinant related to the pheromone response." in: Journal of bacteriology, Vol. 177, Issue 19, pp. 5574-81, (1995) (PubMed).

  • Target
    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
    Alternative Name
    IGF1R (IGF1R Products)
    Background
    IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
    Pathways
    RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy
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