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Details for Product No. ABIN966348

Insulin-Like Growth Factor 1 Receptor (IGF1R) antibody

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Antigen
Synonyms CD221, IGFIR, IGFR, JTK13, IGFIRC, IGFR1, IGF-1R, igf-1r, xigf1r, IGF1R, DKFZp469I0618, xIGF-1R, xIGFR
Reactivity
»Alternatives Human
Host
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 2 references available
Catalog no. ABIN966348
Quantity 0.1 mL
Price
426.25 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days

Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen Ni-NTA purified truncated recombinant IGF1R-His expressed in E. Coli strain BL21 (DE3)
Isotype IgG2b
Purification Crude ascites.

Target Details

Application Details Handling References Alternatives back to top
Alternative Name IGF1R
Background IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.

Application Details

Target Details Handling References Alternatives back to top
Application Notes Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only

References

Target Details Application Details Handling Alternatives back to top
Product cited in: Fujimoto, Tomita, Wakamatsu et al.: "Physical mapping of the conjugative bacteriocin plasmid pPD1 of Enterococcus faecalis and identification of the determinant related to the pheromone response." in: Journal of bacteriology, Vol. 177, Issue 19, pp. 5574-81, 1995 (PubMed).

Scheidegger, Cenni, Picard et al.: "Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects." in: The Journal of biological chemistry, Vol. 275, Issue 49, pp. 38921-8, 2001 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Insulin-Like Growth Factor 1 Receptor (IGF1R)", type "Antibodies"
Hosts (213), (109), (2), (1)
Reactivities (323), (160), (156), (79), (78), (77), (54), (3), (1), (1)
Applications (188), (100), (80), (78), (42), (41), (35), (12), (11), (8), (6), (4), (2), (1), (1), (1)
Conjugates (9), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (5), (2), (1), (1), (1), (1)
Epitopes (26), (25), (24), (16), (16), (16), (15), (10), (6), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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