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NFKBIA antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha)

Details for Product anti-NFKBIA Antibody No. ABIN966365, Supplier: Log in to see
Antigen
  • AI462015
  • Nfkbi
  • IKBA
  • MAD-3
  • NFKBI
  • ECI-6/IKBA
  • RL/IF-1
Alternatives
anti-Human NFKBIA antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Rattus)
369
172
136
17
12
8
6
4
2
1
Host
Rabbit
320
55
5
1
Clonality
Polyclonal
Conjugate
This NFKBIA antibody is un-conjugated
14
11
9
8
6
6
4
3
3
3
3
3
3
3
3
1
Application
Immunohistochemistry (IHC)
260
139
118
58
51
48
34
19
12
10
6
5
4
3
2
1
1
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human IB- around the phosphorylation site of serine 32/36 (H-D-SP-G-L- D-SP -M-K).
Specificity IB- (Ab-32/36) antibody detects endogenous levels of total IB- protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name IkB-alpha (NFKBIA Antibody Abstract)
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Mattioli, Sebald, Bucher et al.: "Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 6336-44, 2004 (PubMed).

Courtois, Smahi, Reichenbach et al.: "A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency." in: The Journal of clinical investigation, Vol. 112, Issue 7, pp. 1108-15, 2003 (PubMed).

Nair, Venkatraman, Maliekal et al.: "NF-kappaB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix." in: Oncogene, Vol. 22, Issue 1, pp. 50-8, 2003 (PubMed).

Fan, Yang, Engelhardt: "Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion." in: Journal of cell science, Vol. 115, Issue Pt 24, pp. 4843-53, 2002 (PubMed).

Schubert, Neeman, Resnick: "A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 14, pp. 1931-3, 2002 (PubMed).

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