Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody

Details for Product No. ABIN966365
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Antigen
Synonyms AI462015, Nfkbi, IKBA, MAD-3, NFKBI, ECI-6/IKBA, RL/IF-1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(316), (167), (146), (42), (40), (16), (14), (2)
Host
Rabbit
(284), (39), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (7), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3)
Application
Immunohistochemistry (IHC)
(242), (117), (111), (55), (52), (44), (40), (19), (16), (13), (9), (7), (5), (3), (2), (1)
Pubmed 5 references available
Quantity 100 μg
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Catalog No. ABIN966365
398.75 $
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human IB- around the phosphorylation site of serine 32/36 (H-D-SP-G-L- D-SP -M-K).
Specificity IB- (Ab-32/36) antibody detects endogenous levels of total IB- protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name IkB-alpha
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Schubert, Neeman, Resnick: "A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 14, pp. 1931-3, 2002 (PubMed).

Fan, Yang, Engelhardt: "Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion." in: Journal of cell science, Vol. 115, Issue Pt 24, pp. 4843-53, 2002 (PubMed).

Nair, Venkatraman, Maliekal et al.: "NF-kappaB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix." in: Oncogene, Vol. 22, Issue 1, pp. 50-8, 2003 (PubMed).

Courtois, Smahi, Reichenbach et al.: "A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency." in: The Journal of clinical investigation, Vol. 112, Issue 7, pp. 1108-15, 2003 (PubMed).

Mattioli, Sebald, Bucher et al.: "Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 6336-44, 2004 (PubMed).

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