Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (C-Term) antibody

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Antigen
Synonyms
ikk-beta, ikk2, ikkb, ikkbeta, IKBKB, IKKB, CG4201, DIK, DLAK, DmIKK, DmIKKBeta, DmIKKb, DmIKKbeta, DmIkkbeta, Dmel\\CG4201, Dmikkb, Dmikkbeta, IK, IKK, IKK-beta, IKKb, IKKbeta, IRD-5, IRD5, Ik, Ikkb, ... show more
ikk-beta, ikk2, ikkb, ikkbeta, IKBKB, IKKB, CG4201, DIK, DLAK, DmIKK, DmIKKBeta, DmIKKb, DmIKKbeta, DmIkkbeta, Dmel\\CG4201, Dmikkb, Dmikkbeta, IK, IKK, IKK-beta, IKKb, IKKbeta, IRD-5, IRD5, Ik, Ikkb, Ikkbeta, Ird-5, Ird5, LRK, Lak, anon-89Bd, dIKK, dIKK-beta, dIKKbeta, dLak, dmIKKbeta, ikk, ird, ird5/DmIkk[beta], IKK2, NFKBIKB, AIM-1, AI132552, IKK-2, IKK[b] show less
Epitope
C-Term
(32), (22), (21), (21), (20), (13), (13), (13), (13), (10), (9), (9), (9), (9), (9), (9), (9), (9), (8), (8), (8), (8), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (4), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(417), (148), (136), (86), (86), (74), (37), (1)
Host
Rabbit
(373), (50), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(26), (26), (26), (16), (16), (16), (10), (10), (10), (10), (10), (10), (10), (10)
Application
Immunohistochemistry (IHC)
(181), (160), (125), (100), (57), (50), (31), (20), (11), (6), (6), (4), (4), (3), (1)
Pubmed 11 references available
Quantity 0.1 mg
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Catalog No. ABIN966372
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very C-terminal residues of human IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)
Alternative Name IKBKB
Background IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta) acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. IKBKB also phosphorylates NCOA3. Component of the I-kappa-B-kinase (IKK) core complex consists of CHUK, IKBKB and IKBKG, probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14.
Synonyms: IKKB
Restrictions For Research Use only
Product cited in: Bruey, Bruey-Sedano, Newman et al.: "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 51897-907, 2004 (PubMed).

Chariot, Leonardi, Muller et al.: "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37029-36, 2002 (PubMed).

Wu, Qin, Hashimoto et al.: "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3549-61, 2002 (PubMed).

Sanz, Sanchez, Lallena et al.: "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation." in: The EMBO journal, Vol. 18, Issue 11, pp. 3044-53, 1999 (PubMed).

Delhase, Hayakawa, Chen et al.: "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 309-13, 1999 (PubMed).

Nemoto, DiDonato, Lin: "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7336-43, 1998 (PubMed).

Hu, Wang: "IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes." in: Gene, Vol. 222, Issue 1, pp. 31-40, 1999 (PubMed).

Shindo, Nakano, Sakon et al.: "Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization." in: Cytogenetics and cell genetics, Vol. 82, Issue 1-2, pp. 32-3, 1998 (PubMed).

Cohen, Henzel, Baeuerle: "IKAP is a scaffold protein of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 292-6, 1998 (PubMed).

Woronicz, Gao, Cao et al.: "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 866-9, 1997 (PubMed).

Mercurio, Zhu, Murray et al.: "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 860-6, 1997 (PubMed).

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