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P21-Activated Kinases 1/2/3 (PAK1/2/3) (pThr402), (pThr421), (pThr423) antibody

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Synonyms X-PAK1, XPak1, pak, pak-1, pakalpha
pThr423, pThr402, pThr421
(15), (9), (7), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(32), (12), (11), (1)
Immunohistochemistry (IHC)
(18), (18), (11), (10), (6), (3), (2)
Pubmed 4 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human PAK1 around the phosphorylation site of threonine 423 (R-S-TP-M-V).
Specificity PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421) antibody detects endogenous levels of PAK1/PAK2/PAK3 only when phosphorylated at threonine 423/402/421.
Alternative Name PAK1/PAK2/PAK3 (PAK1/2/3 Antibody Abstract)
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Wang, Mazumdar, Vadlamudi et al.: "P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium." in: The EMBO journal, Vol. 21, Issue 20, pp. 5437-47, 2002 (PubMed).

Background publications Jung, Traugh: "Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141." in: The Journal of biological chemistry, Vol. 280, Issue 48, pp. 40025-31, 2005 (PubMed).

Parsons, Monypenny, Ameer-Beg et al.: "Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1680-95, 2005 (PubMed).

Lampugnani, Zanetti, Breviario et al.: "VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam." in: Molecular biology of the cell, Vol. 13, Issue 4, pp. 1175-89, 2002 (PubMed).

Catalog No. ABIN966798
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