PAK1/2/3 antibody (AA 391-440)

Catalog No. ABIN1532384

This Rabbit Polyclonal antibody specifically detects PAK1/2/3 in IHC, WB, ELISA and IF. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for PAK1/2/3 antibody (AA 391-440) (ABIN1532384)

Target: PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK1/2/3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-PAK1/2/3 Antibody

Binding Specificity: AA 391-440

Purpose: PAKα/β/γ Antibody

Specificity: PAKα/β/γ Polyclonal Antibody detects endogenous levels of PAKα/β/γ protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PAK1/2/3. AA range:391-440

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PAK1/2/3

Target: PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))

Alternative Name: PAK1/2/3

Background:

Synonyms: PAK1, Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK, PAK2, Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, PAK-2, p58, PAK3, OPHN3, Serine/threonine-p

Background: This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010],

Gene Name: PAK1/PAK2/PAK3

Protein Name: Serine/threonine-protein kinase PAK 1

Molecular Weight: 60 kDa

Gene ID: 5058, 5062, 5063

OMIM: 602590

UniProt: Q13153